2-甲酰基-3-氧代丙酸乙酯合成路线 （共 23 条）
反应条件
sodium ethanolate in ethanol 6 h; Heating / reflux;
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1577302 A1, 2005 ;
Location in patent: Page/Page column 128-129 ;
反应条件
sodium ethanolate in ethanol 6 h; Heating;
参考文献
Komoriya, Satoshi; Haginoya, Noriyasu; Kobayashi, Shozo; Nagata, Tsutomu; Mochizuki, Akiyoshi; Suzuki, Masanori; Yoshino, Toshiharu; Horino, Haruhiko; Nagahara, Takayasu; Suzuki, Makoto; Isobe, Yumiko; Furugoori, Taketoshi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 12 p. 3927 - 3954
反应条件
hydrogenchloride; ethanol; hydroxylamine
参考文献
Kusumi, Takenori; Chang, Conway C.; Wheeler, Margaret; Kubo, Isao; Nakanishi, Koji; Naoki, Hideo
Tetrahedron Letters, 1981 , vol. 22, # 36 p. 3451 - 3454
反应条件
in ethanol T=0 - 20°C; 24 h;
参考文献
Menozzi; Schenone; Mosti; Mattioli
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 997 - 1002
反应条件
1: 1.) (C2H5)3N / 1.) ether, room temp., 1 h; 2.) DMF, -20 deg C -> room temp.; 3 h 2: pyridine / dimethylformamide / 10 h / 70 °C View Scheme
参考文献
Torii, Sigeru; Inokuchi, Tsutomu; Kubota, Minoru
Synthesis, 1986 , # 5 p. 400 - 402
反应条件
in ethanol T=0 - 20°C; 24 h;
参考文献
Holzer, Wolfgang; Seiringer, Gertrud
Journal of Heterocyclic Chemistry, 1993 , vol. 30, # 4 p. 865 - 872
反应条件
sodium ethanolate in ethanol 6 h; Heating / refluxArgon atmosphere;
参考文献
WO2006/97691 A1, ;
Page/Page column 32-33 ;
WO 2006/097691 A1
反应条件
Zinc chloride in ethanol
参考文献
Merck and Co., Inc.
Patent: US4808595 A1, 1989 ;
反应条件
hydrogenchloride; zinc(II) chloride in diethyl ether; ethanol T=80°C; cyclocondensation; 2 h;
参考文献
Dorsey; McDonough; McDaniel; Levin; Newton; Hoffman; Darke; Zugay-Murphy; Emini; Schleif; Olsen; Stahlhut; Rutkowski; Kuo; Lin; Chen; Michelson; Holloway; Huff; Vacca
Journal of Medicinal Chemistry, 2000 , vol. 43, # 18 p. 3386 - 3399
参考文献
SANWA KAGAKU KENKYUSHO CO., LTD.
Patent: EP1595866 A1, 2005 ;
Location in patent: Page/Page column 16 ;
