1-(苯磺酰)-1H-吲哚-2-甲醛合成路线 （共 14 条）
反应条件
lithium diisopropyl amide in tetrahydrofuran T=-78 - 20°C; 4 h;
参考文献
Naik, Nilesh H.; Urmode, Tukaram D.; Sikder, Arun K.; Kusurkar, Radhika S.
Australian Journal of Chemistry, 2013 , vol. 66, # 9 p. 1112 - 1114
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78°C; 4 h; Inert atmosphere;
参考文献
Zhang, Bao; Wee, Andrew G. H.
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 23 p. 4597 - 4608
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, from -78 deg C to 0 deg C, 1 h, 2.) from -78 deg C to room temp., overnight 2: lithium diisopropylamide / tetrahydrofuran; hexane / 1.) -70 deg C, 1.5 h, 2.) from -70 deg C to -5 deg C, 1 h 3: 50 percent / tetrahydrofuran / -65 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 5 p. 757 - 761
反应条件
in tetrahydrofuran T=-65 - 20°C;
参考文献
Saulnier, Mark G.; Gribble, Gordon W.
Journal of Organic Chemistry, 1982 , vol. 47, # 5 p. 757 - 761
反应条件
potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate in dichloromethane T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 18 p. 4548 - 4552
反应条件
1: 1.) n-butyllithium / 1.) THF, hexane, from -78 deg C to 0 deg C, 1 h, 2.) from -78 deg C to room temp., overnight 2: lithium diisopropylamide / tetrahydrofuran; hexane / 1.) -70 deg C, 1.5 h, 2.) from -70 deg C to -5 deg C, 1 h 3: 50 percent / tetrahydrofuran / -65 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 5 p. 757 - 761
反应条件
1: lithium diisopropylamide / tetrahydrofuran; hexane / 1.) -70 deg C, 1.5 h, 2.) from -70 deg C to -5 deg C, 1 h 2: 50 percent / tetrahydrofuran / -65 - 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 5 p. 757 - 761
反应条件
1.1: 18-crown-6 ether; potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C 1.2: 2 h / 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 23 p. 4597 - 4608
反应条件
1: DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C 2: aq. HBr; H2SO4 / CH2Cl2 / 1.5 h View Scheme
参考文献
De Dios, Alfonso; Prieto, Lourdes; Martin, Jose Alfredo; Rubio, Almudena; Ezquerra, Jesus; Tebbe, Mark; Lopez De Uralde, Beatriz; Martin, Justina; Sanchez, Ana; LeTourneau, Deborah L.; McGee, James E.; Boylan, Carole; Parr Jr., Thomas R.; Smith, Michele C.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4559 - 4570
反应条件
1.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C
1.2: 84 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: 75 percent / pyridinium dichromate / dimethylformamide / 20 h / 20 °C
3.1: 93 percent / NaOH / ethanol / 20 h / Heating
View Scheme
参考文献
Mahboobi, Siavosh; Burgemeister, Thomas; Dove, Stefan; Kuhr, Sabine; Popp, Alfred
Journal of Organic Chemistry, 1999 , vol. 64, # 22 p. 8130 - 8137
