(3,3-二乙氧基-1-丙烯-2-基)苯合成路线 （共 12 条）
反应条件
1.1: pyridinium p-toluenesulfonate / cyclohexane / Heating 1.2: ozone / CH2Cl2 / 0.25 h / -78 °C 1.3: 656 mg / dimethyl sulfide / CH2Cl2 / 12 h / 20 °C 2.1: 86 percent / diethyl ether / 1 h / -78 °C 3.1: ozone / CH2Cl2 / 1 h / 20 °C 3.2: 60 percent / sodium hydroxide / H2O; methanol View Scheme
参考文献
Bailey, William F.; Reed, David P.; Clark, Daniel R.; Kapur, Gabriel N.
Organic Letters, 2001 , vol. 3, # 12 p. 1865 - 1867
反应条件
1: 80 percent / NaOH, benzyltriethylammonium chloride / CH2Cl2; H2O / 2 h / 40 °C 2: 74 percent / conc. HCl / tetrahydrofuran; H2O / 8 h / 60 °C 3: Na2SO4 / benzene / 12 h / Ambient temperature 4: 41 percent / benzene / 40 h / 220 °C View Scheme
参考文献
Kagabu, Shinzo; Ando, Chihaya; Ando, Junko
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 6 p. 739 - 752
反应条件
sodium hydroxide
24 h; Heating / reflux;
参考文献
LA JOLLA PHARMACEUTICAL COMPANY
Patent: WO2005/82343 A2, 2005 ;
Location in patent: Page/Page column 84 ;
反应条件
potassium tert-butylate in tetrahydrofuran
T=20°C; 7 h;
参考文献
Bailey, William F.; Reed, David P.; Clark, Daniel R.; Kapur, Gabriel N.
Organic Letters, 2001 , vol. 3, # 12 p. 1865 - 1867
反应条件
potassium hydroxide
T=78°C; 24 h; Yield given. Title compound not separated from byproducts;
参考文献
Kostikov; Varakin; Molchanov; Ogloblin
Russian Journal of Organic Chemistry, 1996 , vol. 32, # 1 p. 25 - 30
反应条件
1: dimethylformamide / 0.5 h / -20 °C
2: 1 h / 58 - 62 °C
View Scheme
参考文献
Crossland, Ingolf
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1987 , vol. 41, # 4 p. 310 - 312
参考文献
Crossland, Ingolf
Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1987 , vol. 41, # 4 p. 310 - 312
参考文献
Normant
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1955 , vol. 240, p. 1435
反应条件
1: 80 percent / NaOH, benzyltriethylammonium chloride / CH2Cl2; H2O / 2 h / 40 °C
2: 74 percent / conc. HCl / tetrahydrofuran; H2O / 8 h / 60 °C
3: Na2SO4 / benzene / 12 h / Ambient temperature
4: 10 percent / benzene / 220 °C
View Scheme
参考文献
Kagabu, Shinzo; Ando, Chihaya; Ando, Junko
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 6 p. 739 - 752
反应条件
in neat (no solvent)
0.0833333 h; Ambient temperature;
参考文献
Coates, Robert M.; Hobbs, Steven J.
Journal of Organic Chemistry, 1984 , vol. 49, p. 140 - 152
