1-苄氧基-4-(3-溴丙氧基)苯合成路线 （共 7 条）
反应条件
potassium carbonate in dichloromethane; acetone
参考文献
Hoffmann-La Roche Inc.
Patent: US4471116 A1, 1984 ;
反应条件
in dichloromethane; N,N-dimethyl-formamide; mineral oil
反应条件
hydrogen; palladium 10 on activated carbon in tetrahydrofuran
P=2068.65 Torr;
参考文献
Butler, Christopher R.; Edwards, James P.; Fourie, Anne M.; Grice, Cheryl A.; Karlsson, Lars; Savall, Brad M.; Tays, Kevin L.; Wei, Jianmei
Patent: US2006/223792 A1, 2006 ;
Location in patent: Page/Page column 23 ;
US 20060223792 A1
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 60 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
1: 1.) sodium hydride / 1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min
2: 61 percent / H2 / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
sodium hydride
1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
反应条件
sodium hydride
1.) DMF, 5 min, 2.) DMF, 60 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Machin, Peter J.; Hurst, David N.; Bradshaw, Rachel M.; Blaber, Leslie C.; Burden, David T.; Melarange, Rosemary A.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 4 p. 503 - 509
