4-氯-N,N-二异丙基苯甲酰胺合成路线 （共 9 条）
反应条件
triethylamine in dichloromethane T=20°C; Inert atmosphere;
参考文献
Schroeder, Nils; Wencel-Delord, Joanna; Glorius, Frank
Journal of the American Chemical Society, 2012 , vol. 134, # 20 p. 8298 - 8301
反应条件
n-butyllithium in diethyl ether; hexane T=0°C; 2 h;
参考文献
Deka, Dibakar C.; Purkayastha, Biswajit; Paul, Maumita
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 10 p. 2641 - 2642
反应条件
1: CH2Cl2 / Ambient temperature 2: 1.) CF3SO3Me, 2.) N-methylmorpholine / 1.) ClCH2CH2Cl, RT, 5 min, 2.) ClCH2CH2Cl, 20 deg C, 7 h View Scheme
参考文献
Synthesis, , # 11 p. 1286 - 1288
反应条件
4-methyl-morpholine; methyl trifluoromethanesulfonate 1.) ClCH2CH2Cl, RT, 5 min, 2.) ClCH2CH2Cl, 20 deg C, 7 h; Yield given. Multistep reaction;
参考文献
Synthesis, , # 11 p. 1286 - 1288
反应条件
chlorine in sulfolane; water T=50°C; 9 h; different benzoic acid derivatives and chlorination or bromination conditions; Product distribution;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1689 - 1696
反应条件
1: para-chloro-benzonitrile; tri-isopropoxy-borane; lithium diisopropyl amide 2: 3-hydroxy-2,2-dimethylpropanol Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 71, # 6 p. 2518 - 2520
反应条件
chlorine in water; acetic acid T=70°C; 9 h;
参考文献
European Journal of Organic Chemistry, , # 8 p. 1689 - 1696
反应条件
chlorine in water; acetic acid T=70°C; 9 h;
参考文献
Dong, Chang-Zhi; Julia, Marc; Tang, Jie
European Journal of Organic Chemistry, 1998 , # 8 p. 1689 - 1696
反应条件
1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / -78 °C
1.2: -78 - -15 °C
2.1: sodium tetrahydroborate / methanol / 5 h / Cooling with ice
3.1: hydrogenchloride / water / 6 h / Reflux
View Scheme
参考文献
Faigl, Ferenc; Thurner, Angelika; Molnar, Balazs; Simig, Gyula; Volk, Balazs
Organic Process Research and Development, 2010 , vol. 14, # 3 p. 617 - 622
