3-[苄基-(2-甲氧基羰基乙基)-氨基]-丙酸乙酯合成路线 （共 21 条）
反应条件
1.1: Na / toluene / 2 h / Heating 1.2: 41 percent / HCl / toluene / Heating 2.1: 73 percent / AcOH / toluene / 2 h / Heating 3.1: NaBH4 / methanol / 1 h / Heating 3.2: 81 percent / NaOH / methanol 4.1: 54 percent / TEA / benzene / 24 h View Scheme
参考文献
Lee, Yeon Sun; Nyberg, Joel; Moye, Sharif; Agnes, Richard S.; Davis, Peg; Ma, Shou-wu; Lai, Josephine; Porreca, Frank; Vardanyan, Ruben; Hruby, Victor J.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 8 p. 2161 - 2165
参考文献
Arjomandi, Omid Khalili; Saemian, Nader; McGeary, Ross P.; Shirvani, Gholamhossein
Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 14 p. 722 - 725
反应条件
copper in methanol
T=20°C; Aza-Michael Addition; 0.3 h;
参考文献
Reddy, K. Rajender; Kumar, Nadakudity S.
Synlett, 2006 , # 14 p. 2246 - 2250
反应条件
triethylamine in N,N-dimethyl-formamide
T=20 - 25°C; 16 h; Molecular sieve; chemoselective reaction;
参考文献
Bhattacharyya, Shubhankar; Pathak, Uma; Mathur, Sweta; Vishnoi, Subodh; Jain, Rajeev
RSC Advances, 2014 , vol. 4, # 35 p. 18229 - 18233
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=25°C; Michael Addition; 2 h; Inert atmosphere;
参考文献
Peeters, Annelies; Ameloot, Rob; De Vos, Dirk E.
Green Chemistry, 2013 , vol. 15, # 6 p. 1550 - 1557
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=25°C; Michael Addition; 2 h; Inert atmosphere;
参考文献
Peeters, Annelies; Ameloot, Rob; De Vos, Dirk E.
Green Chemistry, 2013 , vol. 15, # 6 p. 1550 - 1557
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=25°C; Michael Addition; 24 h; Inert atmosphere;
参考文献
Peeters, Annelies; Ameloot, Rob; De Vos, Dirk E.
Green Chemistry, 2013 , vol. 15, # 6 p. 1550 - 1557
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile
T=25°C; Michael Addition; 2 h; Inert atmosphere;
参考文献
Peeters, Annelies; Ameloot, Rob; De Vos, Dirk E.
Green Chemistry, 2013 , vol. 15, # 6 p. 1550 - 1557
参考文献
Japan Science and Technology Agency; National University Corporation Kagoshima University
Patent: EP1548016 A1, 2005 ;
Location in patent: Page/Page column 14 ;
反应条件
1: 82 percent / NaH / benzene / 3 h / Heating
2: NaBH4 / methanol / 2 h / 0 - 20 °C
3: triethylamine; MeSO2Cl / CH2Cl2 / 0 - 20 °C
View Scheme
参考文献
Chavan, Subhash P.; Khobragade, Dushant A.; Pathak, Ashok B.; Kalkote, Uttam R.
Synthetic Communications, 2007 , vol. 37, # 18 p. 3143 - 3149
