1: 3,4-dihydro-7-chloro-4-methyl-2H-1,4-benzodiazepine-2,5(1H)-dione With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide T=0°C; 0.333333 h; 2: With diethyl chlorophosphate in tetrahydrofuran; N,N-dimethyl-formamide T=0°C; 0.5 h; 3: isocyano-acetic acid ethyl ester With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 20°C;

acetic acid in tetrahydrofuran; N-methyl-acetamide; water; ethyl acetate

potassium tert-butylate in tetrahydrofuran T=-35 - 20°C; Inert atmosphere;

1: 1.) NaH / 1.) THF, DMF, 20 min, 2.) THF, DMF, 30 min 2: 1.) NaH / 1.) DMF, 15 min, 2.) DMF, THF, a.) 30 min, b.) RT, overnight View Scheme

sodium hydride 1.) DMF, 15 min, 2.) DMF, THF, a.) 30 min, b.) RT, overnight; Multistep reaction;

Multistep reaction;