T=130 - 140°C;

sodium hydroxide T=0°C; Methylation; 3.5 h;

N-bromosuccinmide in acetic acid T=20°C;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11342937', constants.ctx, '0')">potassium hydroxide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11342956', constants.ctx, '0')">selenium</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=110&deg;C;&nbsp;P=760&nbsp;Torr;&nbsp;4&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: hydrogen / 10 percent Pd/C / ethanol<br />2: 1.) pyridine; 2.) 220 deg C, heating, 10 min<br /> <br /> &nbsp;

<b>Multi-step reaction with 5 steps<br /> </b>1: hydroxylamine / 0.08 h / |Reflux<br />2: sulfuric acid / 65 &deg;C<br />3: sulfuric acid; dipotassium peroxodisulfate / 0 - 5 &deg;C<br />4: hydrogenchloride / 3 h / |Reflux<br />5: tetrahydrofuran / 1 h / 20 &deg;C<br /> <br /> &nbsp;