1-氯-4-[氯(4-氯苯基)甲基]苯合成路线 （共 22 条）
反应条件
water in acetonitrile T=25°C; Kinetics; Concentration;
参考文献
Streidl, Nicolas; Antipova, Anna; Mayr, Herbert
Journal of Organic Chemistry, 2009 , vol. 74, # 19 p. 7328 - 7334
反应条件
water in acetonitrile T=25°C; product selectivity; var. conc. of reactants; Rate constant;
参考文献
Bentley, T. William; Ryu, Zoon Ha
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 4 p. 761 - 768
反应条件
water in acetonitrile T=25°C; product selectivity; var. conc. of reactants; Rate constant;
参考文献
Bentley, T. William; Ryu, Zoon Ha
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1994 , # 4 p. 761 - 768
反应条件
in acetonitrile T=90°C; 16 h;
参考文献
Song, Kwang-Seop; Lee, Sung-Han; Chun, Hyun Ji; Kim, Jong Yup; Jung, Myung Eun; Ahn, Kwangwoo; Kim, Soo-Un; Kim, Jeongmin; Lee, Jinhwa
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 7 p. 4035 - 4051
反应条件
1: 19 percent / K2CO3 / tetrahydrofuran / 14 h / Heating 2: 96 percent / 10percent aq. NaOH / methanol / 72 h / Heating View Scheme
参考文献
Younes, S.; Baziard-Mouysset, G.; Saqui-Sannes, G. de; Stigliani, J. L.; Payard, M.; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 12 p. 943 - 948
反应条件
in acetonitrile 2 h; Heating;
参考文献
Jones, C. David; Winter, Mark A.; Hirsch, Kenneth S.; Stamm, Nancy; Taylor, Harold M.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 416 - 429
反应条件
sodium hydride 1.) DMF, heating, 15 min, 2.) heating, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Jones, C. David; Winter, Mark A.; Hirsch, Kenneth S.; Stamm, Nancy; Taylor, Harold M.; et al.
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 416 - 429
反应条件
in 1,4-dioxane Reflux;
参考文献
El Hage, Salome; Lajoie, Barbora; Feuillolay, Catherine; Roques, Christine; Baziard, Genevieve
Archiv der Pharmazie, 2011 , vol. 344, # 6 p. 402 - 410
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 35.67 h / 20 - 50 °C / Inert atmosphere 2: n-heptane; dichloromethane / 0.33 h / 20 °C View Scheme
参考文献
Mahoney, Stuart J.; Lou, Tiantong; Bondarenko, Ganna; Fillion, Eric
Organic Letters, 2012 , vol. 14, # 13 p. 3474 - 3477
反应条件
thionyl chloride in cyclohexane
24 h; Heating;
参考文献
Younes, S.; Baziard-Mouysset, G.; Saqui-Sannes, G. de; Stigliani, J. L.; Payard, M.; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 12 p. 943 - 948
