5-硝基-1H-吲唑-3-羧酸乙酯合成路线 （共 7 条）
反应条件
sodium hydroxide; water T=20 - 60°C; pH=~ 2; 2 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2005/92890 A2, 2005 ;
Location in patent: Page/Page column 79 ;
WO 2005/092890 A2
反应条件
sulfuric acid; nitric acid
T=0°C; 2 h;
参考文献
Xie, Wenge; Herbert, Brian; Ma, Jianguo; Nguyen, Truc Minh; Schumacher, Richard; Gauss, Carla Maria; Tehim, Ashok
Patent: US2005/250808 A1, 2005 ;
Location in patent: Page/Page column 38-39 ;
US 20050250808 A1
反应条件
sulfuric acid; nitric acid in water
T=0°C; 2 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION
Patent: WO2005/92890 A2, 2005 ;
Location in patent: Page/Page column 79 ;
WO 2005/092890 A2
反应条件
sulfuric acid
9 h; Heating;
参考文献
Schmidt, Andreas; Beutler, Ariane; Habeck, Tobias; Mordhorst, Thorsten; Snovydovych, Bohdan
Synthesis, 2006 , # 11 p. 1882 - 1894
反应条件
sulfuric acid; nitric acid
T=0°C; 0.166667 h;
参考文献
Crocetti, Letizia; Schepetkin, Igor A.; Cilibrizzi, Agostino; Graziano, Alessia; Vergelli, Claudia; Giomi, Donatella; Khlebnikov, Andrei I.; Quinn, Mark T.; Giovannoni, Maria Paola
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6259 - 6272
反应条件
1: 60 percent / conc. H2SO4; aq. HNO3 / 10 - 20 °C
2: 60 percent / H2SO4 / 9 h / Heating
View Scheme
参考文献
Schmidt, Andreas; Beutler, Ariane; Habeck, Tobias; Mordhorst, Thorsten; Snovydovych, Bohdan
Synthesis, 2006 , # 11 p. 1882 - 1894
反应条件
1: sulfuric acid / 5 h / |Reflux
2: nitric acid; sulfuric acid / 0.17 h / 0 °C
View Scheme
参考文献
Crocetti, Letizia; Schepetkin, Igor A.; Cilibrizzi, Agostino; Graziano, Alessia; Vergelli, Claudia; Giomi, Donatella; Khlebnikov, Andrei I.; Quinn, Mark T.; Giovannoni, Maria Paola
Journal of Medicinal Chemistry, 2013 , vol. 56, # 15 p. 6259 - 6272
