3,3-双(氯甲基)氧杂环丁烷合成路线 （共 32 条）
反应条件
potassium hydroxide in ethanol 72 h; Heating / reflux;
参考文献
Wyeth
Patent: US2005/282826 A1, 2005 ;
Location in patent: Page/Page column 28-29 ;
反应条件
potassium hydroxide; benzene
反应条件
1: SOCl2, pyridine / 14 h / Heating 2: KOH / ethanol / 5 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 65, # 1-2 p. 43 - 48
反应条件
phosphorus pentachloride
参考文献
Zhukova,T.I. et al.
Journal of Organic Chemistry USSR (English Translation), 1975 , vol. 11, p. 2018 - 2019
Zhurnal Organicheskoi Khimii, 1975 , vol. 11, p. 1989
反应条件
in butan-1-ol T=105°C; 270 h;
参考文献
Kireev, I. R.; Kantor, E. A.; Valitov, R. B.; Rakhmankulov, D. L.
Journal of Organic Chemistry USSR (English Translation), 1981 , p. 1366 - 1368
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 7 p. 1536 - 1539
反应条件
1: 82 percent / methanol / 240 h / 80 °C 2: 75 percent / conc. H2SO4 / toluene / 240 h / 130 °C View Scheme
参考文献
Kireev, I. R.; Kantor, E. A.; Valitov, R. B.; Rakhmankulov, D. L.
Journal of Organic Chemistry USSR (English Translation), 1981 , p. 1366 - 1368
Zhurnal Organicheskoi Khimii, 1981 , vol. 17, # 7 p. 1536 - 1539
反应条件
sulfuric acid in water
参考文献
Zarudii, F. S.; Lazareva, D. N.; Kurmaeva, E. S.; Chalova, O. B.; Kiladze, T. K.; et al.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 2 p. 108 - 111
Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 2 p. 161 - 165
参考文献
Campbell
Journal of Organic Chemistry, 1957 , vol. 22, p. 1029,1033
反应条件
ethanol; diethyl malonate
参考文献
Campbell
Journal of Organic Chemistry, 1957 , vol. 22, p. 1029,1033
反应条件
1: 36 percent / Zn, KI / 10 h / 120 °C 2: 40percent NaOH / 70 - 86 °C View Scheme
参考文献
Zarudii, F. S.; Lazareva, D. N.; Kurmaeva, E. S.; Chalova, O. B.; Kiladze, T. K.; et al.
Pharmaceutical Chemistry Journal, 1985 , vol. 19, # 2 p. 108 - 111
Khimiko-Farmatsevticheskii Zhurnal, 1985 , vol. 19, # 2 p. 161 - 165
