(R)-(-)-2-苯丙酸合成路线 （共 166 条）
反应条件
(S)-HBTM; N-ethyl-N,N-diisopropylamine in toluene T=20°C; 10 h; enantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 14-15 p. 2301 - 2304
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 4 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 1 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 18 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 0.3 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
Candida antarctica lipase B; water in tert-butyl methyl ether T=45°C; 5 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 66, # 1-2 p. 113 - 119
反应条件
water; hydrophobic polystyrene-supported sulfonic acid 72 h; Heating; Title compound not separated from byproducts.;
参考文献
Organic Letters, , vol. 5, # 2 p. 101 - 103
反应条件
1: phenyllithium With copper(l) iodide in diethyl ether T=0°C; 2: (1S,2Z)-1-({[(2S)-2-methoxy-2-phenylethoxy]methyl}(dimethyl)silyl)-1-methylbut-2-enyl acetate in diethyl ether T=-80 - 0°C; 3: With ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile T=23°C; Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 59, # 38 p. 7527 - 7533
反应条件
1: phenyllithium With copper(l) iodide in diethyl ether T=0°C; 2: (1S,E)-1-({[(2S)-2-methoxy-2-phenylethoxy]methyl}(dimethyl)silyl)-1-methylbut-2-enyl acetate in diethyl ether T=-80 - 0°C; 3: With ruthenium trichloride; sodium periodate in tetrachloromethane; water; acetonitrile T=23°C; Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 59, # 38 p. 7527 - 7533
反应条件
1.1: 45 percent / (-)-sparteine; oxygen / palladium(II) acetate / toluene / 80 °C / 760 Torr 2.1: phosphorus tribromide; pyridine / diethyl ether / -20 - 0 °C 2.2: dimethylformamide / 80 °C 2.3: hydrochloric acid / CH2Cl2 / Heating View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 44, # 3 p. 557 - 562
