(R)-(-)-2-苯丙酸合成路线 （共 166 条）
反应条件
ammonium cerium(IV) nitrate; acetic acid in water; acetonitrile 0.25 h;
参考文献
Vedejs; Kruger; Lee; Sakata; Stec; Suna
Journal of the American Chemical Society, 2000 , vol. 122, # 19 p. 4602 - 4607
反应条件
sodium periodate; ruthenium trichloride in tetrachloromethane; water; acetonitrile T=20°C; Sharpless oxidation; 1.5 h;
参考文献
Organic Letters, , vol. 9, # 24 p. 5095 - 5098
反应条件
1: 25 percent / hydrogen / Rh<P(C6H5)3>3Cl / ethanol; methanol / 48 h 2: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature 3: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H2O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 22 p. 7447 - 7455
反应条件
sodium chlorite; sodium dihydrogen phosphate dihydrate; 2-methyl-but-2-ene in tert-butyl alcohol T=0 - 20°C; 2 h;
参考文献
Krishna, Palakodety Radha; Arun Kumar, Pendyala Venkata; Mallula, Venkata Satyanarayana; Ramakrishna, Kallaganti V.S.
Tetrahedron, 2013 , vol. 69, # 10 p. 2319 - 2326
反应条件
1: 1.) magnesium, / 1.) THF, 45 min, 2.) THF, 0 deg C, 1 h 2: 94 percent / H2 / Rh<P(C6H5)3>3Cl / benzene / 23 h / Ambient temperature 3: 1.) N-chlorosuccinimide, dimethyl sulfide, 2.) triethylamine / 1.) toluene, -25 deg C, 5 h, 2.) toluene, 10 min; to r.t., 15 min 4: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature 5: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H2O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 22 p. 7447 - 7455
反应条件
1: 1.) potassium hexamethyldisilazane / 1.) THF, -78 deg C, 1 h, 2.) -78 deg C, 3.5 h 2: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature 3: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H2O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 22 p. 7447 - 7455
反应条件
1: 1.) N-chlorosuccinimide, dimethyl sulfide, 2.) triethylamine / 1.) toluene, -25 deg C, 5 h, 2.) toluene, 10 min; to r.t., 15 min 2: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature 3: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H2O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 22 p. 7447 - 7455
反应条件
1: 94 percent / H2 / Rh<P(C6H5)3>3Cl / benzene / 23 h / Ambient temperature 2: 1.) N-chlorosuccinimide, dimethyl sulfide, 2.) triethylamine / 1.) toluene, -25 deg C, 5 h, 2.) toluene, 10 min; to r.t., 15 min 3: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature 4: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H2O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 22 p. 7447 - 7455
反应条件
1: hydrogen, HCl / 10 percent palladium on carbon / methanol / 15 h / 2585.7 Torr / Ambient temperature 2: 1.) periodic acid, benzyltrimethylammonium hydroxide, 2.) conc. HCl / methanol; H2O / 24 h / Ambient temperature; 1.) pH= 6, 2.) pH= 2 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 110, # 22 p. 7447 - 7455
反应条件
1: TsOH 2: LDA 3: LDA 4: H2 / Pd/C 5: KOH / ethanol 7: chromium trioxide, aq. sulfuric acid 8: aq. KOH, phosophate buffer (pH 6.5) / 2 h / 30 °C / Alcaligenes bronchisepticus KU 1201; also S-enantiomer View Scheme
参考文献
Journal of the American Chemical Society, , vol. 114, # 15 p. 6256 - 6257
