反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 - 135 °C 2.1: lithium hydroxide hydrate / tetrahydrofuran; water / 4 h / 50 °C 2.2: pH 2 3.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 50 °C 4.1: triethylamine / dichloromethane / 20 °C 5.1: 10 palladium on activated charcoal; hydrogen / methanol / 20 °C View Scheme
参考文献
Lin, Xingyu; Huang, Xi-Ping; Chen, Gang; Whaley, Ryan; Peng, Shiming; Wang, Yanli; Zhang, Guoliang; Wang, Simon X.; Wang, Shaohui; Roth, Bryan L.; Huang, Niu
Journal of Medicinal Chemistry, 2012 , vol. 55, # 12 p. 5749 - 5759