N-BOC-吲哚-5-硼酸频那酯合成路线 （共 10 条）
反应条件
tris-(dibenzylideneacetone)dipalladium(0); potassium acetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in N,N-dimethyl-formamide T=100°C; Inert atmosphere;
参考文献
MERCK SHARP and DOHME CORP.; MCCOMAS, Casey Cameron; LIVERTON, Nigel J.; HABERMANN, Joerg; KOCH, Uwe; NARJES, Frank; LI, Peng; PENG, Xuanjia; SOLL, Richard; WU, Hao; PALANI, Anandan; DAI, Xing; LIU, Hong; HE, Shuwen; DANG, Qung
Patent: WO2013/34048 A1, 2013 ;
Location in patent: Page/Page column 90 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane T=100°C; 48 h;
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6812 - 6820
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile
参考文献
Craig, Sandra; Gao, Lei; Lee, Irene; Gray, Thomas; Berdis, Anthony J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2437 - 2451
反应条件
1: 86 percent / DMAP / acetonitrile / 1 h / 20 °C 2: KOAc; PdCl2(dppf) / dioxane / 48 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6812 - 6820
反应条件
1: 86 percent / DMAP / acetonitrile / 1 h / 20 °C 2: KOAc; PdCl2(dppf) / dioxane / 48 h / 100 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6812 - 6820
反应条件
1: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 25 °C 2: potassium acetate; tris-(dibenzylideneacetone)dipalladium(0); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / N,N-dimethyl-formamide / 100 °C / |Inert atmosphere View Scheme
反应条件
in diethyl ether T=20°C; Inert atmosphereMolecular sieve;
参考文献
Journal of the American Chemical Society, , vol. 135, # 7 p. 2552 - 2559
反应条件
sodium periodate; ammonium acetate; water in acetone T=23°C; 24 h;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; RITTER, Tobias; FURUYA, Takeru; TANG, Pingping
Patent: WO2010/59943 A2, 2010 ;
Location in patent: Page/Page column 85 ;
反应条件
1: With sodium hydroxide in methanol T=23°C; 0.25 h; 2: With silver trifluoromethanesulfonate in methanol T=0°C; 0.5 h; 3: With 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in hexadeuterioacetone 1 h; Molecular sieve;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; RITTER, Tobias; FURUYA, Takeru; TANG, Pingping
Patent: WO2010/59943 A2, 2010 ;
Location in patent: Page/Page column 89; 90 ;
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate in 1,4-dioxane T=100°C; Suzuki coupling; 72 h;
参考文献
Prieto, Monica; Zurita, Esther; Rosa, Esmeralda; Munoz, Lourdes; Lloyd-Williams, Paul; Giralt, Ernest
Journal of Organic Chemistry, 2004 , vol. 69, # 20 p. 6812 - 6820
