反应条件
1: 64.6 percent / aq. NaOH / 3.5 h / 0 °C 2: 62 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 1.) 0 deg C, 2.0 h, 2.) room temperature, 15.0 h 3: 1.) N-methylmorpholine, 1-hydroxybenzotriazole, 2.) hydrogen / 2.) palladium black / 1.) DMF, water, room temperature, 20.0 h, 2.) methanol, 2.5 h View Scheme
参考文献
Khare; Becker; Naider
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 650 - 656
