2-甲硫基-4-氨基嘧啶-5-羧酸乙酯合成路线 （共 23 条）
反应条件
ammonium hydroxide; triethylamine in tetrahydrofuran T=10 - 55°C; Reagent/catalyst;
参考文献
ELI LILLY AND COMPANY; DECIPHERA PHARMACEUTICALS, LLC; ALLGEIER, Matthew Carl; FLYNN, Daniel L.; KAUFMAN, Michael D.; PATEL, Phenil J.; WOLFANGEL, Craig D.
Patent: WO2013/134243 A1, 2013 ;
Location in patent: Page/Page column 15-16 ;
反应条件
in DMF (N,N-dimethyl-formamide) T=20 - 50°C; 0.333333 h;
参考文献
Lang, Hengyuan; Lan, Jiong; Fang, Yunfeng
Patent: US2005/20590 A1, 2005 ;
Location in patent: Page/Page column 27 ;
US 20050020590 A1
反应条件
triethylamine in tetrahydrofuran; hexane; ethyl acetate
参考文献
Warner-Lambert Company
Patent: US6498163 B1, 2002 ;
US 6498163 B1
反应条件
sodium hydroxide in water T=50°C; 0.166667 h; diastereoselective reaction;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 46, # 3 p. 363 - 366
反应条件
sodium hydroxide in water T=20°C; 1 h; Reflux; diastereoselective reaction;
参考文献
Chemistry of Heterocyclic Compounds, , vol. 46, # 3 p. 363 - 366
反应条件
in acetic acid 1 h; Reflux;
参考文献
Gefenas; Stankeviciute; Malinauskas; Tumkevicius
Chemistry of Heterocyclic Compounds, 2010 , vol. 46, # 3 p. 363 - 366
反应条件
in toluene 20 h; Heating;
参考文献
Urleb, Uros; Stanovnik, Branko; Stibilj, Vekoslava; Tisler, Miha
Heterocycles, 1986 , vol. 24, # 7 p. 1899 - 1909
反应条件
1: sodium ethylate; ethanol 2: water; KOH View Scheme
参考文献
Journal of Organic Chemistry, , vol. 21, p. 567,571
反应条件
1: potassium hydroxide / methanol / 0 - 5 °C 2: sodium hydroxide / water / 1 h / 20 °C / Reflux View Scheme
参考文献
Chemistry of Heterocyclic Compounds, , vol. 46, # 3 p. 363 - 366
反应条件
in pyridine 1 h; Heating;
参考文献
Yamazaki, Chiji
Journal of Organic Chemistry, 1981 , vol. 46, # 20 p. 3956 - 3959
