3-甲氧基-2-甲基苯甲腈合成路线 （共 8 条）
反应条件
1: With boron trichloride; tetra-(n-butyl)ammonium iodide in dichloromethane T=-78 - 20°C; 3.25 h; 2: With water in dichloromethane 0.5 h;
参考文献
Pfizer Inc
Patent: US2006/160786 A1, 2006 ;
Location in patent: Page/Page column 36-37 ;
US 20060160786 A1
参考文献
Mukharji,P.C. et al.
Indian Journal of Chemistry, 1971 , vol. 9, p. 515 - 523
反应条件
1: 2-methoxy-6-chlorotoluene With triphenylphosphine; niobium bromide; zinc in tetrahydrofuran
T=60°C; 0.5 h; Inert atmosphere;
2: potassium cyanide in tetrahydrofuran
T=50 - 60°C; Inert atmosphere;
参考文献
Yestrepsky, Bryan D.; Xu, Yuanxi; Breen, Meghan E.; Li, Xiaoqin; Rajeswaran, Walajapet G.; Ryu, Jenny G.; Sorenson, Roderick J.; Tsume, Yasuhiro; Wilson, Michael W.; Zhang, Wenpeng; Sun, Duxin; Sun, Hongmin; Larsen, Scott D.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 7 p. 1880 - 1897
反应条件
potassium carbonate in dichloromethane; acetone
参考文献
American Home Products Corporation
Patent: US4244966 A1, 1981 ;
参考文献
Carpenter; Easter
Journal of Organic Chemistry, 1955 , vol. 20, p. 401,407
反应条件
1: Fe, aq. HCl
2: (i) (diazotization), (ii) aq. H2SO4
4: Py
View Scheme
参考文献
Mukharji,P.C. et al.
Indian Journal of Chemistry, 1971 , vol. 9, p. 515 - 523
反应条件
1: (i) (diazotization), (ii) aq. H2SO4
3: Py
View Scheme
参考文献
Mukharji,P.C. et al.
Indian Journal of Chemistry, 1971 , vol. 9, p. 515 - 523
参考文献
Mukharji,P.C. et al.
Indian Journal of Chemistry, 1971 , vol. 9, p. 515 - 523
