4,4-(1,4-丁烷二yl)二氧基二苯甲醛合成路线 （共 7 条）
反应条件
ethanol; sodium
Heatingovernight;
参考文献
Guilani, Bardia; Rasco, Melvin L.; Hermann, Christine F. K.; Gibson, Harry W.
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 4 p. 1007 - 1009
反应条件
1: 4-hydroxy-benzaldehyde With sodium hydride in N,N-dimethyl-formamide
T=20°C; 1.5 h;
2: 4-chloro-butyl chloride in N,N-dimethyl-formamide
T=70°C; 2 h; Further stages.;
参考文献
Bertini, Vincenzo; Pocci, Marco; Alfei, Silvana; Idini, Barbara; Lucchesini, Francesco
Tetrahedron, 2007 , vol. 63, # 47 p. 11672 - 11680
反应条件
potassium carbonate in acetonitrile
24 h; Reflux;
参考文献
Talotta, Carmen; Gaeta, Carmine; Qi, Zhenhui; Schalley, Christoph A.; Neri, Placido
Angewandte Chemie - International Edition, 2013 , vol. 52, # 29 p. 7437 - 7441
Angew. Chem., 2013 , vol. 125, # 29 p. 7585 - 7589,5
反应条件
in N,N-dimethyl-formamide
0.5 h;
参考文献
Agarwal; Saxena; Jain; Anand; Sur; Srim al; Dhawan
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1990 , vol. 29, # 1 p. 80 - 84
反应条件
N,N-dimethyl-formamide
T=140°C;
参考文献
Greber
Makromolekulare Chemie, 1957 , vol. 22, p. 183,185, 190
反应条件
sodium ethanolate
1.) ethanol, reflux, 4 h, 2.) reflux, 48 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806
反应条件
1: 83.1 percent / piperidine, glacial acetic acid / benzene / Heating
2: 2.) NaOH / 1.) water, ethanol, heating, 2 h, 2.) ethylene glycol, heating, 40 h
3: 1.) acetic anhydride, 2.) ammonia / 1.) heating, 6 h, 2.) ethyl acetate, 2 h
4: 1 h / 200 - 220 °C
View Scheme
参考文献
Nesunts, N. S.; Avetisyan, S. A.; Dzhagatspanyan, I. A.; Akopyan, N. E.; Mndzhoyan, O. L.
Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 7 p. 480 - 484
Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 7 p. 801 - 806
