N-(9-芴甲氧羰酰基)-N-甲基-L-苯丙氨酸合成路线 （共 9 条）
反应条件
triethylsilane; aluminium trichloride in chloroform T=20°C;
参考文献
Buba, Annette E.; Koch, Stefan; Kunz, Horst; Loewe, Holger
European Journal of Organic Chemistry, 2013 , # 21 p. 4509 - 4513
反应条件
sodium carbonate in 1,4-dioxane a) ice-bath, 1 h, b) r.t., 3 h;
参考文献
Bain, J. D.; Wacker, Dean A.; Kuo, Eric E.; Lyttle, Matthew H.; Chamberlin, A. Richard
Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4615 - 4625
反应条件
1: N-methyl-N-nosyl-L-phenylalanine phenacyl ester With benzenethiol sodium salt in N,N-dimethyl-formamide T=20°C; 3 h; Inert atmosphere; 2: With sodium carbonate in water pH=9; 3: (9H-Fluoren-9-yl)-methyl chloroformate in 1,4-dioxane T=0°C;
参考文献
Leggio, Antonella; Belsito, Emilia Lucia; De Marco, Rosaria; Liguori, Angelo; Perri, Francesca; Viscomi, Maria Caterina
Journal of Organic Chemistry, 2010 , vol. 75, # 5 p. 1386 - 1392
反应条件
1: With toluene-4-sulfonic acid in toluene 0.5 h; Heating; 2: With triethylsilane; trifluoroacetic acid in dichloromethane T=20°C; 24 h; Further stages.;
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 24 p. 5878 - 5881
反应条件
1: toluene-4-sulfonic acid / toluene / 0.5 h / Reflux 2: triethylsilane; trifluoroacetic acid / chloroform / 16 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 68, # 31 p. 6186 - 6192
反应条件
1: sodium carbonate / 1,4-dioxane; water / 22 h / 0 - 20 °C 2: toluene-4-sulfonic acid / toluene / 0.5 h / Reflux 3: triethylsilane; trifluoroacetic acid / chloroform / 16 h / 20 °C View Scheme
参考文献
Tetrahedron, , vol. 68, # 31 p. 6186 - 6192
反应条件
Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 38, # 42 p. 7307 - 7310
反应条件
1: With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran 1 h; Cooling with ice; 2: With ammonium hydroxide in tetrahydrofuran T=20°C; Cooling with ice; 3: With piperidine in N,N-dimethyl-formamide 24 h;
参考文献
Watts, R.Edward; Forster, Anthony C.
Biochemistry, 2010 , vol. 49, # 10 p. 2177 - 2185
反应条件
1: With chloroformic acid ethyl ester; triethylamine in tetrahydrofuran 1 h; Cooling with ice; 2: With ammonium hydroxide in tetrahydrofuran T=20°C; Cooling with ice;
参考文献
Watts, R.Edward; Forster, Anthony C.
Biochemistry, 2010 , vol. 49, # 10 p. 2177 - 2185
