3-(三氟甲基)苯甲酸乙酯合成路线 （共 13 条）
反应条件
4 A molecular sieve; potassium carbonate; palladium diacetate in toluene T=80°C; P=760.051 Torr; 15 h;
参考文献
Munday, Rachel H.; Martinelli, Joseph R.; Buchwald, Stephen L.
Journal of the American Chemical Society, 2008 , vol. 130, # 9 p. 2754 - 2755
反应条件
[2,2']bipyridinyl; cupric trifluoroacetate in acetonitrile T=20°C; 12 h; Schlenk techniqueInert atmosphereMolecular sieve;
参考文献
Huang, Yuanyuan; Fang, Xin; Lin, Xiaoxi; He, Weiming; Yuan, Yaofeng; Weng, Zhiqiang; Li, Huaifeng; Huang, Kuo-Wei
Tetrahedron, 2012 , vol. 68, # 48 p. 9949 - 9953,5
反应条件
4 A molecular sieve; (Ph3P)PdCl2 in tetrahydrofuran T=100°C; P=22800 Torr; 24 h;
参考文献
Urata, Hisao; Hu, Nan-Xing; Maekawa, Hisayuki; Fuchikami, Takamasa
Tetrahedron Letters, 1991 , vol. 32, # 36 p. 4733 - 4736
反应条件
palladium (II) trifluoroacetate; 1,3-bis-(diphenylphosphino)propane in 1-methyl-pyrrolidin-2-one T=150°C; 16 h; Inert atmosphere;
参考文献
Shang, Rui; Fu, Yao; Li, Jia-Bin; Zhang, Song-Lin; Guo, Qing-Xiang; Liu, Lei
Journal of the American Chemical Society, 2009 , vol. 131, p. 5738 - 5739
反应条件
copper(l) iodide; 1,10-phenanthroline; cesium fluoride in diethylene glycol dimethyl ether T=80°C; 24 h; Inert atmosphere;
参考文献
Kondo, Hideaki; Oishi, Masahiro; Fujikawa, Kenichi; Amii, Hideki
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 8 p. 1247 - 1252
反应条件
oxygen; triethylamine tris(hydrogen fluoride) in N,N-dimethyl-formamide T=25°C; 2.5 h;
参考文献
Novak, Petr; Lishchynskyi, Anton; Grushin, Vladimir V.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 31 p. 7767 - 7770
反应条件
Titanium(IV) oxide; trifluoroacetic acid in acetonitrile 24 h; Ambient temperatureIrradiation; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society - Series Chemical Communications, , # 17 p. 1359 - 1361
反应条件
pyridine; copper(l) iodide T=200°C;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 44 p. 11628 - 11631
Angew. Chem., , vol. 125, # 44 p. 11842 - 11845,4
反应条件
sodium hydride in various solvent(s) Heating;
参考文献
Green, Neal J.; Xiang, Jason; Chen, Jing; Chen, Lihren; Davies, Audrey M.; Erbe, Dave; Tam, Steve; Tobin, James F.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 13 p. 2991 - 3013
反应条件
hydrogenchloride; sodium tetrahydroborate; sodium hydride Yield given. Multistep reaction;
参考文献
Maryanoff; McComsey; Gardocki; Shank; Costanzo; Nortey; Schneider; Setler
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1433 - 1454
