1-硝基-2-丙基磺酰基苯合成路线 （共 5 条）
反应条件
sodium hydrogencarbonate in water
T=90°C; 17 h;
参考文献
SmithKline Beecham Corporation
Patent: US6884801 B1, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
dihydrogen peroxide in acetic acid
1.) below 80 deg C, 80 min 2.) reflux, 2 h;
参考文献
Courtin, Alfred; Tobel, Hans-Rudolf von; Auerbach, Guenther
Helvetica Chimica Acta, 1980 , vol. 63, # 6 p. 1412 - 1419
反应条件
sodium hydrogencarbonate in water
T=90°C; 16 h;
参考文献
Hodson, Stephen J.; Bishop, Michael J.; Speake, Jason D.; Navas III, Frank; Garrison, Deanna T.; Bigham, Eric C.; Saussy Jr., David L.; Liacos, James A.; Irving, Paul E.; Jeffrey Gobel; Sherman, Bryan W.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2229 - 2239
反应条件
1: 83.9 percent / 1.) NaOH / ethanol / 1.) 15 min 2.) reflux, 14 h
2: 81.5 percent / H2O2 / acetic acid / 1.) below 80 deg C, 80 min 2.) reflux, 2 h
View Scheme
参考文献
Courtin, Alfred; Tobel, Hans-Rudolf von; Auerbach, Guenther
Helvetica Chimica Acta, 1980 , vol. 63, # 6 p. 1412 - 1419
反应条件
hydrogen; 5percent Pd/C in ethanol
P=2585.81 Torr; 1 h;
参考文献
Hodson, Stephen J.; Bishop, Michael J.; Speake, Jason D.; Navas III, Frank; Garrison, Deanna T.; Bigham, Eric C.; Saussy Jr., David L.; Liacos, James A.; Irving, Paul E.; Jeffrey Gobel; Sherman, Bryan W.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 11 p. 2229 - 2239
