5-羟基甲基呋喃-2-羧酸乙酯合成路线 （共 12 条）
反应条件
1: 84 percent / p-toluenesulfonic acid / diethyl ether / 1.5 h / Ambient temperature 2: 93 percent / LiAlH4 / diethyl ether / 1 h / -40 °C 3: MnO2 / petroleum ether; diethyl ether / 168 h / Ambient temperature 4: pyridinium p-toluenesulfonate / ethanol / 12 h / 55 °C View Scheme
参考文献
Tsuboi, Sadao; Mimura, Shigetoshi; Ono, Shin-ichiro; Watanabe, Kenji; Takeda, Akira
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, p. 1807 - 1812
反应条件
hydrogenchloride; tetrachloromethane
参考文献
Haworth; Jones
Journal of the Chemical Society, 1944 , p. 667,670
反应条件
1: With sodium ethanolate in ethanol
T=20°C; 24 h;
2: With ion-exchange resin
Acidic conditions;
参考文献
Hopf, Henning; Abhilash
Synlett, 2009 , # 20 p. 3349 - 3351
反应条件
silver nitrate in water; acetone
T=22°C; 6 h;
参考文献
Tsuboi, Sadao; Mimura, Shigetoshi; Ono, Shin-ichiro; Watanabe, Kenji; Takeda, Akira
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, p. 1807 - 1812
参考文献
Abbott Laboratories
Patent: US5486525 A1, 1996 ;
反应条件
1: 5N NaOH / dioxane
2: HCl gas
View Scheme
参考文献
Talaga, Patrice; Matagne, Alain; Klitgaard, Henrik
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1313 - 1316
反应条件
1: 37 percent Spectr. / SeO2 / various solvent(s) / 2 h / Heating
2: 94 percent / NBS, benzoyl peroxide / CCl4 / 2 h / Heating
3: 30 percent / AgNO3 / acetone; H2O / 6 h / 22 °C
View Scheme
参考文献
Tsuboi, Sadao; Mimura, Shigetoshi; Ono, Shin-ichiro; Watanabe, Kenji; Takeda, Akira
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, p. 1807 - 1812
反应条件
1: 94 percent / NBS, benzoyl peroxide / CCl4 / 2 h / Heating
2: 30 percent / AgNO3 / acetone; H2O / 6 h / 22 °C
View Scheme
参考文献
Tsuboi, Sadao; Mimura, Shigetoshi; Ono, Shin-ichiro; Watanabe, Kenji; Takeda, Akira
Bulletin of the Chemical Society of Japan, 1987 , vol. 60, p. 1807 - 1812
反应条件
in benzene
T=80°C; 4 h;
参考文献
Pevzner, L. M.; Ignat'ev, V. M.; Ionin, B. I.
J. Gen. Chem. USSR (Engl. Transl.), 1987 , vol. 57, # 10 p. 2259 - 2262,2020 - 2022
参考文献
Haworth; Jones
Journal of the Chemical Society, 1944 , p. 667,670
