2-氨基-4-甲氧基-N-[8-(苯基甲基)-8-氮杂双环[3.2.1]辛烷-3-基]嘧啶-5-甲酰胺合成路线 （共 13 条）
反应条件
2: NH2OH*HCl / 0.67 h
3: 80 percent / Na / pentan-1-ol / 80 °C / Heating
4: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: NH2OH*HCl / 0.67 h
2: 80 percent / Na / pentan-1-ol / 80 °C / Heating
3: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 80 percent / Na / pentan-1-ol / 80 °C / Heating
2: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
chloroformic acid ethyl ester; triethylamine
1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT; Yield given. Multistep reaction;
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
2: 70 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
2: 55 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
2: 55 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
2: 33 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
2: 74 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
反应条件
1: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
2: 70 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
