反式-2-(4-氨基环己基)乙酸乙酯盐酸盐合成路线 (共 4 条)
反应条件
1: 2-(4-nitrophenyl)acetic acid With hydrogen; palladium 10 on activated carbon in water T=44 - 58°C; Inert atmosphereAutoclaveIndustry scale; 2: ethanol With hydrogenchloride in water RefluxIndustry scale;
参考文献
RICHTER GEDEON NYRT.; MATHE, Tibor, Bence; HEGEDUS, Laszl; CZIBULA, Laszl; JUHASZ, Balint; NAGYNE BAGDY, Judit; MARKOS, Denes
Patent: WO2010/70368 A1, 2010 ;
Location in patent: Page/Page column 4 ;
反应条件
hydrogenchloride 4 h; Heating / reflux;
参考文献
US2009/42943 A1, ;
Page/Page column 10 ;
US 20090042943 A1
反应条件
1: 1139 g / H2, aq. NaOH / Raney Ni / 62.5 h / 20 - 130 °C / 91380.1 - 129701 Torr 2: HCl / 4 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 5 p. 760 - 771
反应条件
hydrogenchloride 4 h; Heating; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 5 p. 760 - 771