2-(1-苯并噻吩-3-基)乙酸乙酯合成路线 （共 4 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 1 h;
参考文献
Venkatesan, Aranapakam Mudumbai; Santos, Osvaldo Dos; Gu, Yansong
Patent: US2005/4162 A1, 2005 ;
Location in patent: Page/Page column 18 ;
US 20050004162 A1
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: EP761666 A2, 1997 ;
反应条件
1: 1) NaH, 2) CuBr / 1) quinoline, mineral oil, 60-65 deg C, 2) 100-105 deg C, overnight
2: 1) NaOEt / 1) EtOH, reflux, 1.5 h, 2) EtOH, reflux, 3 h
View Scheme
参考文献
Sura, Tushar P.; MacDowell, Denis W. H.
Journal of Organic Chemistry, 1993 , vol. 58, # 16 p. 4360 - 4369
反应条件
sodium ethanolate
1) EtOH, reflux, 1.5 h, 2) EtOH, reflux, 3 h; Multistep reaction. Yields of byproduct given;
参考文献
Sura, Tushar P.; MacDowell, Denis W. H.
Journal of Organic Chemistry, 1993 , vol. 58, # 16 p. 4360 - 4369
