3-氯-4-甲氧基苯乙腈合成路线 （共 18 条）
反应条件
1: aq.-ethanolic KOH-solution 2: methanol. sodium methylate / 185 °C View Scheme
参考文献
Hromatka
Chemische Berichte, 1942 , vol. 75, p. 123,129
反应条件
1: aq.-ethanolic KOH-solution 2: potassium hydroxide; sodium hydroxide / 210 °C 3: diethyl ether; methanol / Erhitzen des Reaktionsprodukts mit wss. Kalilauge View Scheme
参考文献
Hromatka
Chemische Berichte, 1942 , vol. 75, p. 123,129
反应条件
(i) aq. HBr, (ii) /BRN= 1098229/, HCl; Multistep reaction;
参考文献
Kuchar; Brunova; Rejholec; et al.
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 5 p. 1723 - 1735
参考文献
Munavalli,S. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 3311 - 3318
反应条件
1: 35 percent / LiAlH4 / tetrahydrofuran / 5 h / Heating 2: 67 percent / 20percent NaOH / diethyl ether / Ambient temperature View Scheme
参考文献
Charifson; Wyrick; Hoffman; Ademe Simmons; Bowen; McDougald; Mailman
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 1941 - 1946
反应条件
1: With potassium tert-butylate in tetrahydrofuran
T=-78°C; 1.66667 h;
2: With methanol in tetrahydrofuran
0.5 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2008/141119 A2, 2008 ;
Location in patent: Page/Page column 75 ;
WO 2008/141119 A2
反应条件
potassium tert-butylate in tetrahydrofuran; methanol; water
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
sodium cyanide in ethanol; water
T=20°C;
参考文献
Roche Palo Alto LLC
Patent: US2007/88053 A1, 2007 ;
Location in patent: Page/Page column 19 ;
反应条件
chlorine in acetic acid
0.5 h; Ambient temperature;
参考文献
Charifson; Wyrick; Hoffman; Ademe Simmons; Bowen; McDougald; Mailman
Journal of Medicinal Chemistry, 1988 , vol. 31, # 10 p. 1941 - 1946
反应条件
in dimethyl sulfoxide
参考文献
Kuchar; Brunova; Rejholec; et al.
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 1 p. 122 - 136
