4-甲氧基-3-甲基苯乙腈合成路线 （共 11 条）
反应条件
18-crown-6 ether in acetonitrile T=60°C; 9 h;
参考文献
Synthetic Communications, , vol. 22, # 17 p. 2571 - 2578
反应条件
1: 1.) Mg / 1.) THF, 2.) THF, reflux, 5 min 2: NaBH4 / methanol / 0.25 h / Ambient temperature 3: PBr3, pyridine / 3 h / Ambient temperature 4: 18-crown-6 / acetonitrile / 9 h / 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 22, # 17 p. 2571 - 2578
反应条件
1: NaBH4 / methanol / 0.25 h / Ambient temperature 2: PBr3, pyridine / 3 h / Ambient temperature 3: 18-crown-6 / acetonitrile / 9 h / 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 22, # 17 p. 2571 - 2578
反应条件
1: PBr3, pyridine / 3 h / Ambient temperature 2: 18-crown-6 / acetonitrile / 9 h / 60 °C View Scheme
参考文献
Synthetic Communications, , vol. 22, # 17 p. 2571 - 2578
反应条件
1: aqueous formaldehyde; aqueous HCl; petroleum ether View Scheme
参考文献
Journal of Organic Chemistry, , vol. 16, p. 457,458
参考文献
Journal of Organic Chemistry, , vol. 16, p. 457,458
参考文献
Wenner
Journal of Organic Chemistry, 1951 , vol. 16, p. 457,458
反应条件
1: boron tribromide / dichloromethane / 20.5 h / -78 - 20 °C 2: sodium hydroxide / 1.5 h / 20 °C View Scheme
参考文献
MERCK PATENT GMBH; WUCHERER-PLIETKER, Margarita; WERKMANN, Daniela; GIGOUT, Anne; KUHN, Daniel; SAWATZKY, Edgar
Patent: WO2014/32755 A2, 2014 ;
反应条件
boron tribromide in dichloromethane T=-78 - 20°C; 20.5 h;
参考文献
MERCK PATENT GMBH; WUCHERER-PLIETKER, Margarita; WERKMANN, Daniela; GIGOUT, Anne; KUHN, Daniel; SAWATZKY, Edgar
Patent: WO2014/32755 A2, 2014 ;
Location in patent: Page/Page column 149 ;
反应条件
1: ethanolic sodium ethylate 2: aqueous H2SO4 View Scheme
参考文献
Wenner
Journal of Organic Chemistry, 1951 , vol. 16, p. 457,458
