2-(2-氯-3,4-二甲氧基苯基)乙腈合成路线 （共 16 条）
反应条件
diborane in tetrahydrofuran
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 74 percent / B2H6 / tetrahydrofuran 2: 44 percent 3: 85 percent / H2SO4 / trifluoroacetic acid / Heating 4: BBr3 / CH2Cl2 View Scheme
参考文献
Weinstock; Wilson; Ladd; Brush; Pfeiffer; Kuo; Holden; Yim; Hahn; Wardell Jr.; Tobia; Setler; Sarau; Ridley
Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 973 - 975
反应条件
1: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 2: 19 percent / 2.5 h / Heating 3: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 2: 19 percent / 2.5 h / Heating 3: 69 percent / TFA, 36 N H2SO4 / 3.5 h / 25 °C 4: 95 percent / BBr3 / CH2Cl2 / 3 h / 25 °C View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 74 percent / borane / tetrahydrofuran / 1.5 h / Heating 2: 19 percent / 2.5 h / Heating View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
1: 74 percent / B2H6 / tetrahydrofuran 2: 19 percent 3: 68 percent / H2SO4 / trifluoroacetic acid / 25 °C 4: BBr3 / CH2Cl2 View Scheme
参考文献
Weinstock; Wilson; Ladd; Brush; Pfeiffer; Kuo; Holden; Yim; Hahn; Wardell Jr.; Tobia; Setler; Sarau; Ridley
Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 973 - 975
反应条件
1: 51 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 2: Me3SiI / CHCl3; tetrahydrothiophene 1,1-dioxide / 72 h / 50 °C View Scheme
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
in dimethyl sulfoxide
1.25 h;
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
反应条件
18-crown-6 ether in acetonitrile
168 h; Heating;
参考文献
McCarthy, James R.; McCowan, Jefferson; Zimmerman, Mark B.; Wenger, Marcia A.; Emmert, Lee W.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1586 - 1590
反应条件
1: 100 percent / NaBH4 / aq. ethanol / 1 h / 25 °C
2: 97 percent / 12N aq. HCl
3: 96 percent / dimethylsulfoxide / 1.25 h
View Scheme
参考文献
Weinstock; Ladd; Wilson; Brush; Yim; Gallagher Jr.; McCarthy; Silvestri; Sarau; Flaim
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2315 - 2325
