2,6-二氯吡啶-4-甲酸叔丁酯合成路线 （共 8 条）
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in 1-methyl-pyrrolidin-2-one T=20 - 35°C; 19 h;
参考文献
McDermott, Todd S.; Bhagavatula, Lakshmi; Borchardt, Thomas B.; Engstrom, Kenneth M.; Gandarilla, Jorge; Kotecki, Brian J.; Kruger, Albert W.; Rozema, Michael J.; Sheikh, Ahmad Y.; Wagaw, Seble H.; Wittenberger, Steven J.
Organic Process Research and Development, 2009 , vol. 13, # 6 p. 1145 - 1155
参考文献
Schmidt, Gunther; Reber, Stefan; Bolli, Martin H.; Abele, Stefan
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 595 - 604
反应条件
sulfuric acid in tetrahydrofuran; dichloromethane T=0 - 20°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/108358 A2, 2005 ;
Location in patent: Page/Page column 76 ;
WO 2005/108358 A2
参考文献
Syntex (U.S.A.) LLC
Patent: US2003/144303 A1, 2003 ;
反应条件
sulfuric acid in N-methyl-acetamide; thionyl chloride; chloroform; cyclohexane; N,N-dimethyl-aniline; tert-butyl alcohol
反应条件
1: Citrazinic acid With anhydrous tetramethylammonium chloride; trichlorophosphate T=130°C; 18 h; Inert atmosphere; 2: tert-butyl alcohol With pyridine T=0 - 20°C; Inert atmosphere;
参考文献
Lorimer, Anna V.; O'Connor, Patrick D.; Brimble, Margaret A.
Synthesis, 2008 , # 17 art. no. P04408SS, p. 2764 - 2770
反应条件
1: iron (III) acetylacetonate / 1-methyl-pyrrolidin-2-one; tetrahydrofuran / -77 - 20 °C 2: hydrogenchloride / isopropyl alcohol / 3 h / 80 °C View Scheme
参考文献
Bolli, Martin; Lescop, Cyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat; Velker, Jorg
Patent: US2011/212998 A1, 2011 ;
US 20110212998 A1
反应条件
1: With sulfuric acid T=80°C; 28 h; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2009/24905 A1, 2009 ;
Location in patent: Page/Page column 51 ;
WO 2009/024905 A1
