N-叔丁氧羰基-1,3-丙二胺合成路线 （共 26 条）
参考文献
Jolidon, Synese; Rodriguez Sarmiento, Rosa Maria; Thomas, Andrew William; Wyler, Rene
Patent: US2003/236304 A1, 2003 ;
反应条件
in tetrahydrofuran Ambient temperature;
参考文献
Huang; Dredar; Manneh; Blankenship; Fries
Journal of medicinal chemistry, 1992 , vol. 35, # 13 p. 2414 - 2418
反应条件
1: 1.) methanesulfonic acid, aq. potassium acetate, 3.) aq. NaOH / 1) 1,2-dimethoxyethane, neutralised to bromocresol green, room temperature, 1 h; 2) acetone, room temperature, overnight, reflux, 1 h; 3) MeOH, room temperature, 1 h 2: 98 percent / H2 / Pd/C / ethanol / 18 h / 2585.7 Torr / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 20 p. 2975 - 2982
反应条件
1: 1.) Et3N, ethyl carbonochloridate, 2.) 20percent aq. NH3 / 1.) THF, -10 deg C, 20 min., 2.) -10 deg C to room temp., overnight 2: 93 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., 3: 59 percent / NH3, H2 / Raney Ni / ethanol / 8 h / 50 °C / 15514.4 Torr View Scheme
参考文献
Synthesis, , # 3 p. 259 - 261
反应条件
1: 93 percent / Et3N, trifluoroacetic anhydride / tetrahydrofuran / 1 h / 0 deg C to room temp., 2: 59 percent / NH3, H2 / Raney Ni / ethanol / 8 h / 50 °C / 15514.4 Torr View Scheme
参考文献
Synthesis, , # 3 p. 259 - 261
反应条件
1: 81 percent / KI, Aliquat 336, NaN3 / CH2Cl2 / 8 h / 110 °C 2: 86 percent / H2 / Pd/C (5percent) / ethanol / 8 h / 1125.09 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 76, # 4 p. 1636 - 1648
反应条件
1: 69 percent / Ph3P, DEAD / tetrahydrofuran / Ambient temperature 2: 88 percent / Zn, 1.) M aq. KH2PO4 / tetrahydrofuran / 4 h / Ambient temperature 3: 95 percent / H2 / 10percent Pd/C / methanol / 1 h / Ambient temperature View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 8 p. 2143 - 2161
反应条件
1: 88 percent / Zn, 1.) M aq. KH2PO4 / tetrahydrofuran / 4 h / Ambient temperature 2: 95 percent / H2 / 10percent Pd/C / methanol / 1 h / Ambient temperature View Scheme
参考文献
Journal of Chemical Research, Miniprint, , # 8 p. 2143 - 2161
反应条件
in chloroform T=20°C;
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 9 p. 4457 - 4478
反应条件
in chloroform 24 h; Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 57, # 21 p. 5687 - 5692
