2-甲基-2,3-二苯基-丙酸合成路线 （共 15 条）
反应条件
oxonium; methyllithium 1) ether, 0 -> 25 deg C, 90 min 2) HMPA, 0 deg C; Yield given. Multistep reaction;
参考文献
Gilday, John P.; Paquette, Leo A.
Tetrahedron Letters, 1988 , vol. 29, # 36 p. 4505 - 4508
反应条件
methanol; potassium hydroxide in water
T=20°C;
参考文献
Poslusney, Michael S.; Sevel, Christian; Utley, Thomas J.; Bridges, Thomas M.; Morrison, Ryan D.; Kett, Nathan R.; Sheffler, Douglas J.; Niswender, Colleen M.; Daniels, J. S.; Conn, P. J.; Lindsley, Craig W.; Wood, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6923 - 6928,6
反应条件
1: K / diethyl ether; 2,2,4-trimethyl-pentane
2: (i) Li, Et2O, (ii) (heating), (iii) /BRN= 1900390/
View Scheme
参考文献
Zimmerman,H.E.; Zweig,A.
Journal of the American Chemical Society, 1961 , vol. 83, p. 1196 - 1213
反应条件
1: liq. NH3, Li / diethyl ether
2: SO2Cl2, (PhCO)2O2
3: (i) Li, Et2O, (ii) (heating), (iii) /BRN= 1900390/
View Scheme
参考文献
Zimmerman,H.E.; Zweig,A.
Journal of the American Chemical Society, 1961 , vol. 83, p. 1196 - 1213
反应条件
1: 1.) Mg / 1.) ether, 2a.) -78 deg C, 2b.) 20 deg C
2: 92 percent / pyridine, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h / 20 °C
3: 1.) sodium α-(dimethylamino)naphthalenide / 1.) benzene, HMPA, 30 s, 2.) 30 min
4: 89 percent / KOH/H2O / ethane-1,2-diol / 2 h / Heating
View Scheme
参考文献
Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G.
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702
反应条件
1: SO2Cl2, (PhCO)2O2
2: (i) Li, Et2O, (ii) (heating), (iii) /BRN= 1900390/
View Scheme
参考文献
Zimmerman,H.E.; Zweig,A.
Journal of the American Chemical Society, 1961 , vol. 83, p. 1196 - 1213
反应条件
1: 1.) Mg / 1.) ether, 2a.) -78 deg C, 2b.) 20 deg C
2: 92 percent / pyridine, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h / 20 °C
3: 1.) sodium α-(dimethylamino)naphthalenide / 1.) benzene, HMPA, 30 s, 2.) 30 min
4: 89 percent / KOH/H2O / ethane-1,2-diol / 2 h / Heating
View Scheme
参考文献
Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G.
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702
反应条件
1: 1.) sodium α-(dimethylamino)naphthalenide / 1.) benzene, HMPA, 30 s, 2.) 30 min
2: 89 percent / KOH/H2O / ethane-1,2-diol / 2 h / Heating
View Scheme
参考文献
Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G.
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702
反应条件
1: 92 percent / pyridine, 4-(dimethylamino)pyridine / CH2Cl2 / 48 h / 20 °C
2: 1.) sodium α-(dimethylamino)naphthalenide / 1.) benzene, HMPA, 30 s, 2.) 30 min
3: 89 percent / KOH/H2O / ethane-1,2-diol / 2 h / Heating
View Scheme
参考文献
Ghosh, Subrata; Pardo, Simon N.; Salomon, Robert G.
Journal of Organic Chemistry, 1982 , vol. 47, # 24 p. 4692 - 4702
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 8 h / |Reflux
2: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 - 20 °C
3: methanol; potassium hydroxide / water / 20 °C
View Scheme
参考文献
Poslusney, Michael S.; Sevel, Christian; Utley, Thomas J.; Bridges, Thomas M.; Morrison, Ryan D.; Kett, Nathan R.; Sheffler, Douglas J.; Niswender, Colleen M.; Daniels, J. S.; Conn, P. J.; Lindsley, Craig W.; Wood, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6923 - 6928,6
