3,3-二甲基-4-苯基-2-氮杂环丁酮合成路线 （共 13 条）
反应条件
n-butyllithium; ammonium chloride; benzaldehyde; diisopropylamine; sodium chloride in tetrahydrofuran; hexane
参考文献
Nippon Steel Corporation; Nippon Steel Chemical Co., Ltd.
Patent: US5866592 A1, 1999 ;
反应条件
trimethylsilyl iodide in dichloromethane
T=25°C; 7 h;
参考文献
Burnett; Hart; Liu
Journal of Organic Chemistry, 1986 , vol. 51, # 10 p. 1929 - 1930
反应条件
lithium aluminium tetrahydride; chloro-trimethyl-silane; water; ethyl acetate in diethyl ether
1.) 0 deg C, 1hr; 2.) room temp., 2 hrs.; 3.) -78 deg C to -30 deg C, overnight (one-pot);
参考文献
Andreoli, P.; Cainelli, G.; Contento, M.; Giacomini, D.; Martelli, G.; Panunzio, M.
Tetrahedron Letters, 1986 , vol. 27, # 15 p. 1695 - 1698
反应条件
1: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 2.) THF, from -78 deg C to 25 deg C, 20 h
2: 81 percent / trimethylsilyl iodide / CH2Cl2 / 7 h / 25 °C
View Scheme
参考文献
Burnett; Hart; Liu
Journal of Organic Chemistry, 1986 , vol. 51, # 10 p. 1929 - 1930
反应条件
1: 1.) n-BuLi, 2.) trimethylchlorosilane / 1.) 20 min.,then cool to 0 deg C, THF, 57 min., 2.) 0 deg C, 30 min., THF
View Scheme
参考文献
Colvin; McGarry; Nugent
Tetrahedron, 1988 , vol. 44, # 13 p. 4157 - 4172
反应条件
1.1: tetrahydrofuran / 2 h / 0 °C
1.2: 0.5 h / 0 °C
2.1: zinc(II) iodide / diethyl ether / 0.5 h / 20 °C
2.2: 2 h / 20 °C
3.1: methylmagnesium bromide / diethyl ether / 48 h / Reflux
View Scheme
参考文献
Ramachandran, P. Veeraraghavan; Biswas, Debanjan; Chen, Guang-Ming
Heterocycles, 2011 , vol. 82, # 2 p. 1423 - 1433
反应条件
lithium diisopropyl amide
1.) THF, -78 deg C, 2.) THF, from -78 deg C to 25 deg C, 20 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Burnett; Hart; Liu
Journal of Organic Chemistry, 1986 , vol. 51, # 10 p. 1929 - 1930
反应条件
lithium diisopropyl amide
1.) THF, -78 deg C, 1 h, 2.) THF, -70 deg C, 1 h, room temp., 2 h; Yield given. Multistep reaction;
参考文献
Uyehara; Suzuki; Yamamoto
Tetrahedron Letters, 1989 , vol. 30, # 32 p. 4275 - 4278
反应条件
tris(pentafluorophenyl)-borane
1.) toluene, a) -78 deg C, 4 h, b) RT, 12 h, 2.) toluene. ether, RT, 1 d; Yield given. Multistep reaction;
参考文献
Ishihara, Kazuaki; Hanaki, Naoyuki; Funahashi, Miyuki; Miyata, Mayumi; Yamamoto, Hisashi
Bulletin of the Chemical Society of Japan, 1995 , vol. 68, # 6 p. 1721 - 1730
反应条件
Yield given. Multistep reaction;
参考文献
Hart, David J.; Kanai, Ken-ichi; Thomas, Dudley G.; Yang, Teng-Kuei
Journal of Organic Chemistry, 1983 , vol. 48, # 3 p. 289 - 294
