(1,1-二甲基-2-丙炔)-苯胺合成路线 （共 15 条）
反应条件
1: 74 percent / CuCl / tetrahydrofuran / 14 h / Heating 2: 1.) n-butyllithium / 1.) Et2O, hexane, -65 deg C, 10 min, 2.) Et2O, hexane, RT, 2 h View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
1: 74 percent / CuCl / tetrahydrofuran / 14 h / Heating 2: 99 percent / H2 / 10percent Pd/C / ethanol; ethyl acetate / 4 h 3: 57 percent / HNO3, H2SO4 / 0.25 h / -5 °C 4: H2 / 10percent Pd/C / ethanol; ethyl acetate / 6 h View Scheme
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
copper(l) chloride in tetrahydrofuran
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US6017924 A1, 2000 ;
反应条件
copper(l) chloride in tetrahydrofuran 14 h; Heating;
参考文献
Hamann, Lawrence G.; Higuchi, Robert I.; Zhi, Lin; Edwards, James P.; Wang, Xiao-Ning; Marschke, Keith B.; Kong, James W.; Farmer, Luc J.; Jones, Todd K.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 4 p. 623 - 639
反应条件
copper(l) chloride in tetrahydrofuran
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US6017924 A1, 2000 ;
反应条件
aniline; copper(l) chloride in tetrahydrofuran
参考文献
Ligand Pharmaceuticals Incorporated
Patent: US5693647 A1, 1997 ;
反应条件
copper bronze; water; copper; triethylamine; copper(l) iodide in tetrahydrofuran
T=60 - 70°C; 4 h;
参考文献
Cooper; Lucas; Taylor; Ward; Williamson
Synthesis, 2001 , # 4 p. 621 - 625
反应条件
triethylamine; Cu2Cl2; copper
T=10 - 20°C; 2 h; Under nitrogen;
参考文献
Al-Awar, Rima Salim; Hecker, Kyle Andrew; Ray, James Edward; Huang, Jianping; Joseph, Sajan; Li, Tiechao; Paal, Michael; Rathnachalam, Radhakrishnan; Shih, Chuan; Waid, Philip Parker; Zhou, Xun; Zhu, Guoxin
Patent: US2003/229026 A1, 2003 ;
Location in patent: Page 21 ;
US 20030229026 A1
参考文献
Wolf; Ramin
Justus Liebigs Annalen der Chemie, 1959 , vol. 626, p. 47,49
反应条件
copper(I) bromide in acetonitrile
0.5 h; Ambient temperature;
参考文献
Geri, Roberto; Polizzi, Carmela; Lardicci, Luciano; Caporusso, Anna Maria
Gazzetta Chimica Italiana, 1994 , vol. 124, # 6 p. 241 - 248
