2-(4,5-二氢-1H-咪唑-2-基)-吡啶合成路线 （共 11 条）
反应条件
trichloroisocyanuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=-15°C; 0.05 h;
参考文献
Synlett, , # 15 p. 2803 - 2805
反应条件
trichloroisocyanuric acid in neat (no solvent)
T=110°C; 0.133333 h; chemoselective reaction;
参考文献
Hojati, Seyedeh Fatemeh; Nezhadhoseiny, Seyede Atefe
Journal of the Serbian Chemical Society, 2012 , vol. 77, # 9 p. 1181 - 1189,9
反应条件
N-bromosuccinmide in dichloromethane
T=0 - 20°C;
参考文献
Fujioka, Hiromichi; Murai, Kenichi; Ohba, Yusuke; Hiramatsu, Atsushi; Kita, Yasuyuki
Tetrahedron Letters, 2005 , vol. 46, # 13 p. 2197 - 2199
反应条件
hydrazine hydrate in ethanol; water; ethylenediamine; acetone
参考文献
SmithKline Beckman Corporation
Patent: US4680304 A1, 1987 ;
反应条件
1,3-bis-(diphenylphosphino)propane; caesium carbonate; palladium dichloride in toluene
16 h; Inert atmosphereReflux;
参考文献
Geden, Joanna V.; Pancholi, Alpa K.; Shipman, Michael
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4158 - 4164
反应条件
1,3-bis-(diphenylphosphino)propane; caesium carbonate; palladium dichloride in toluene
16 h; Inert atmosphereReflux;
参考文献
Geden, Joanna V.; Pancholi, Alpa K.; Shipman, Michael
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4158 - 4164
反应条件
1: CH2Cl2 / 0.5 h / 0 °C
2: N-bromosuccinimide / CH2Cl2 / 20 °C
View Scheme
参考文献
Fujioka, Hiromichi; Murai, Kenichi; Kubo, Ozora; Ohba, Yusuke; Kita, Yasuyuki
Tetrahedron, 2007 , vol. 63, # 3 p. 638 - 643
反应条件
in dichloromethane
48 h; RefluxInert atmosphere;
参考文献
Gaertner, Felix; Cozzula, Daniela; Losse, Sebastian; Boddien, Albert; Anilkumar, Gopinatan; Junge, Henrik; Schulz, Thomas; Marquet, Nicolas; Spannenberg, Anke; Gladiali, Serafino; Beller, Matthias
Chemistry - A European Journal, 2011 , vol. 17, # 25 p. 6998 - 7006
参考文献
Walter; Freiser
Analytical Chemistry, 1954 , vol. 26, p. 217,218
参考文献
Lions; Martin
Journal of the American Chemical Society, 1958 , vol. 80, p. 1591
