4-(4-吗啉基)苯甲酸合成路线 （共 10 条）
反应条件
hydrogenchloride; sodium hydroxide in water
参考文献
Tian, Wei
Patent: US2003/171581 A1, 2003 ;
反应条件
hydrogenchloride; sodium hydroxide in water
参考文献
Tian, Wei
Patent: US2003/171581 A1, 2003 ;
反应条件
sodium hydroxide 5 h; Reflux;
参考文献
Raparti, Vyankatesh; Chitre, Trupti; Bothara, Kailas; Kumar, Vanaja; Dangre, Sudarshan; Khachane, Chetan; Gore, Suraj; Deshmane, Bhavana
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 3954 - 3960
反应条件
hydrogenchloride; sodium hydroxide
参考文献
Tian, Wei
Patent: US2003/171581 A1, 2003 ;
反应条件
potassium hydroxide in toluene T=150°C; 1 h; microwave irradiation;
参考文献
Tetrahedron, , vol. 64, # 23 p. 5604 - 5619
反应条件
1: dimethylformamide / 100 °C 2: aq. HCl / 100 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 5 p. 1529 - 1534
反应条件
1: Et3N / dimethylsulfoxide / 0.5 h 2: aq. NaOH / dimethylformamide / 2 h View Scheme
参考文献
Chemistry Letters, , vol. 35, # 10 p. 1090 - 1091
反应条件
1: methanol With thionyl chloride Cooling with ice; 2: 4-(4-morpholinyl)-benzoic acid 1.5 h; Reflux;
参考文献
Mochizuki, Akiyoshi; Nagata, Tsutomu; Kanno, Hideyuki; Suzuki, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1623 - 1642
反应条件
4-methyl-morpholine; sodium borohydride; acetic acid in tetrahydrofuran; methanol; water
参考文献
US6610704 B1, ;
US 6610704 B1
反应条件
1.1: thionyl chloride / Cooling with ice
1.2: 1.5 h / Reflux
2.1: potassium permanganate; N-benzyl-N,N,N-triethylammonium chloride / dichloromethane / 2 h / 20 °C
3.1: AlCl3, aluminium chloride; dimethylsulfide / dichloromethane / 8 h / 20 °C
3.2: ice
View Scheme
参考文献
Mochizuki, Akiyoshi; Nagata, Tsutomu; Kanno, Hideyuki; Suzuki, Makoto; Ohta, Toshiharu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 5 p. 1623 - 1642
