4-氨基-2-氯嘧啶合成路线

Glaxosmithkline LLC; Aubart, Kelly M.; Benowitz, Andrew B.; Fang, Yuhong; Hoffman, James; Karpinski, Joseph M.; Knox, Andrew Nicholson; Liao, Xiangmin; Qin, Donghui; Shi, Dongchuan; Spletstoser, Jared T.
Patent: US2013/345120 A1, 2013 ;
Location in patent: Page/Page column ;

7461-50-94-氨基-2-氯嘧啶+

124-41-4甲醇钠

3289-47-24-氨基-2-甲氧基嘧啶

参考文献

PFIZER LIMITED; PFIZER INC.
Patent: WO2005/49616 A1, 2005 ;
Location in patent: Page/Page column 80 ;
WO 2005/049616 A1

67-56-1甲醇+

7461-50-94-氨基-2-氯嘧啶+

124-41-4甲醇钠

3289-47-24-氨基-2-甲氧基嘧啶

参考文献

Hutchison MediPharma Enterprises Limeted
Patent: US2008/255172 A1, 2008 ;
Location in patent: Page/Page column 65 ;

7461-50-94-氨基-2-氯嘧啶

71-30-7胞嘧啶

参考文献

Hilbert
Journal of the American Chemical Society, 1934 , vol. 56, p. 190,192

7461-50-94-氨基-2-氯嘧啶+

143-33-9氰化钠

245321-46-44-氨基-2-嘧啶甲腈

参考文献

Caravatti, Giorgio; Rahuel, Joseph; Brigitte, Gay; Furet, Pascal
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 1973 - 1978

7461-50-94-氨基-2-氯嘧啶

63286-28-23-氯-2-肼-1,2-二氢吡嗪盐酸盐

参考文献

AMGEN INC.
Patent: WO2009/64418 A1, 2009 ;
Location in patent: Page/Page column 85 ;
WO 2009/064418 A1