2,6-dimethylpyridine; triphenylmethane tetrafluoroborate in dichloromethane 1 h; Ambient temperaturefurther reagents: tritylperchlorate;

1: With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: With tert-butyloxycarbonyl-L-aspartic acid in tetrahydrofuran; hexane T=-78°C; 3 h;

hydrogen; Pd-BaSO4 in toluene 48 h;

lithium diisopropyl amide in tetrahydrofuran; hexane T=-78°C; 0.5 h;

1: 3,4-dihydro-2-methyl-naphthalen-1-yl acetate With methyllithium; lithium bromide; 4-methyl-N-[(1S)-2-methyl-1-({((2S)-3-methyl-2-{[(4-methylphenyl)sulfonyl]amino}butyl)[(4-methylphenyl)sulfonyl]amino}methyl)propyl]benzenesulfonamide in tetrahydrofuran; diethyl ether T=-78°C; 1 h; 2: chloro-trimethyl-silane in tetrahydrofuran; diethyl ether T=-78°C; Title compound not separated from byproducts;

triethylamine in anhydrous dichloroethane 12 h; CoolingReflux;

1.1: NaH / dimethylformamide 2.1: aq. HBr 3.1: LDA / tetrahydrofuran 3.2: tetrahydrofuran View Scheme

1.1: aq. HBr 2.1: LDA / tetrahydrofuran 2.2: tetrahydrofuran View Scheme

1.1: NaH 2.1: NaH / dimethylformamide 3.1: aq. HBr 4.1: LDA / tetrahydrofuran 4.2: tetrahydrofuran View Scheme

1: Et2Zn / diethyl ether 2: 26 percent / 9,10-dicyanoanthracene; biphenyl; Cu(OAc)2 / acetonitrile / Irradiation View Scheme