(Z)-2-甲氧基苯甲酰氯肟合成路线 （共 15 条）
反应条件
1: NaOMe / methanol / 20 °C 2: 100 percent / aq. NaOH / methanol View Scheme
参考文献
Zhu, Shirong; Shi, Shuhao; Gerritz, Samuel W.
Tetrahedron Letters, 2011 , vol. 52, # 31 p. 4001 - 4004
反应条件
(i), (ii) KOH, aq. EtOH; Multistep reaction;
参考文献
Doyle,F.P. et al.
Journal of the Chemical Society, 1963 , p. 5845 - 5854
反应条件
1: 88 percent / triethylamine; MgSO4 / toluene / 20 °C 2: 79 percent / aq. sodium hydroxide / aq. ethanol / Heating 3: oxalyl chloride / benzene / 1.5 h / Heating 4: 49 percent / triethylamine / benzene / 1 h / Heating View Scheme
参考文献
Golebiewski; Gucma
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 2 p. 509 - 513
反应条件
1: acetoacetic acid methyl ester With sodium methylate in methanol 2: N-hydroxy-2-methoxybenzimidoyl chloride With sodium methylate; triethylamine in methanol; ethanol; N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
Zhu, Shirong; Shi, Shuhao; Gerritz, Samuel W.
Tetrahedron Letters, 2011 , vol. 52, # 31 p. 4001 - 4004
反应条件
triethylamine in ethanol; N,N-dimethyl-formamide T=20°C; 16 h; regioselective reaction;
参考文献
Zhu, Shirong; Shi, Shuhao; Gerritz, Samuel W.
Tetrahedron Letters, 2011 , vol. 52, # 31 p. 4001 - 4004
反应条件
triethylamine; thiourea in tetrahydrofuran Ambient temperature;
参考文献
Kim, Jae Nyoung; Ryu, Eung K.
Tetrahedron Letters, 1993 , vol. 34, # 51 p. 8283 - 8284
反应条件
triethylamine in benzene T=20°C;
参考文献
Lukevics; Arsenyan; Shestakova
Chemistry of Heterocyclic Compounds, 2000 , vol. 36, # 10 p. 1226 - 1231
反应条件
hydrogenchloride; Oxonereg;; silica gel
T=20°C; 0.15 h;
参考文献
Bigdeli, Mohammad A.; Mahdavinia, Gholam Hossein; Jafari, Saeed
Journal of Chemical Research, 2007 , # 1 p. 26 - 28
反应条件
in DMF (N,N-dimethyl-formamide)
T=20 - 50°C; 5 h;
参考文献
ELI LILLY AND COMPANY
Patent: WO2005/19184 A1, 2005 ;
Location in patent: Page/Page column 36 ;
WO 2005/019184 A1
反应条件
1: 99 percent / hydroxylamine hydrochloride, 50percent NaOH / ethanol; H2O / 1 h / 25 - 30 °C
2: 57 percent / N-chlorosuccinimide, HCl gas / dimethylformamide
View Scheme
参考文献
Liu, Kou-Chang; Shelton, Becky R.; Howe, Robert K.
Journal of Organic Chemistry, 1980 , vol. 45, # 19 p. 3916 - 3918
