1,3-二溴-5-(氯甲基)苯合成路线 （共 4 条）
反应条件
18-crown-6 ether in acetonitrile T=20°C;
参考文献
SAINT LOUIS UNIVERSITY; RUMINSKI, Peter; GRIGGS, David
Patent: WO2014/15054 A1, 2014 ;
Location in patent: Page/Page column 199 ;
反应条件
in 15-crown-5; acetonitrile T=20°C;
参考文献
ALTANA PHARMA AG
Patent: WO2004/12731 A1, 2004 ;
Location in patent: Page/Page column 19 ;
WO 2004/012731 A1
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane
T=0 - 20°C; 24.5 h;
参考文献
COMENTIS, INC.; PURDUE RESEARCH FOUNDATION
Patent: WO2009/42694 A1, 2009 ;
Location in patent: Page/Page column 114 ;
WO 2009/042694 A1
反应条件
thionyl chloride in DMF (N,N-dimethyl-formamide)
0.5 h;
参考文献
ALTANA PHARMA AG
Patent: WO2004/12731 A1, 2004 ;
Location in patent: Page/Page column 19 ;
WO 2004/012731 A1
