3,3-二甲氧基丙酸甲酯合成路线 （共 56 条）
反应条件
oxygen; acetic acid; palladium diacetate; cerium(III) chloride in methanol T=80°C; P=760.051 Torr; 4.5 h;
参考文献
Tamaso, Ken-Ichi; Hatamoto, Yuji; Obora, Yasushi; Sakaguchi, Satoshi; Ishii, Yasutaka
Journal of Organic Chemistry, 2007 , vol. 72, # 23 p. 8820 - 8823
反应条件
hydrogenchloride in water
参考文献
Ube Industries, Ltd.
Patent: US4440928 A1, 1984 ;
反应条件
1: formic acid ethyl ester With sodium hydride in diethyl ether T=0°C; Argon atmosphere; 2: methyl 3,3-dimethoxy-propanoate T=0 - 20°C; 1.66667 h; Argon atmosphere; 3: With water
参考文献
WO2006/97691 A1, ;
Page/Page column 32 ;
WO 2006/097691 A1
反应条件
sodium hydride 1.) ether; 2.) ether, 5 deg C, 10 h; room temp., overnight; Yield given. Multistep reaction;
参考文献
Synthesis, , # 5 p. 400 - 402
反应条件
sodium hydride 1.) dioxane, 50 deg C, 2.) reflux; Yield given. Multistep reaction;
参考文献
Winckelmann, Ib; Larsen, Erik H.
Synthesis, 1986 , # 12 p. 1041 - 1044
反应条件
methanol; sodium 1.) reflux, 30 min., 2.) toluene, redlux; Yield given. Multistep reaction;
参考文献
Winckelmann, Ib; Larsen, Erik H.
Synthesis, 1986 , # 12 p. 1041 - 1044
反应条件
acetic acid T=70°C; 4.5 h;
参考文献
SANWA KAGAKU KENKYUSHO CO., LTD.
Patent: EP1595866 A1, 2005 ;
Location in patent: Page/Page column 18 ;
反应条件
toluene-4-sulfonic acid in toluene T=140°C; 1.5 h; Inert atmosphere;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 16 p. 5836 - 5857
反应条件
hydrogenchloride in dichloromethane 2 h; Ambient temperature;
参考文献
Berkaoui, M'hamed; Outurquin, Francis; Paulmier, Claude
Tetrahedron, 1998 , vol. 54, # 31 p. 9055 - 9066
反应条件
sodium hydride 1.) dioxane, 50 deg C, 2.) reflux; Yield given. Multistep reaction;
参考文献
Katritzky, Alan R.; Baykut, Gokhan; Rachwal, Stanislaw; Szafran, Miroslaw; Caster, Kenneth C.; Eyler, John
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1989 , p. 1499 - 1506
