2-硝基-4-羟基苯甲酸合成路线 （共 10 条）
反应条件
1: With sulfuric acid; sodium nitrite in water T=0 - 5°C; 1.25 h; 2: With urea in water T=0°C; 0.166667 h; 3: With sulfuric acid in water 3 h; Reflux;
参考文献
WYETH
Patent: US2005/70584 A1, 2005 ;
Location in patent: Page/Page column 24 ;
反应条件
water; hydrogen bromide; acetic acid T=130 - 150°C; 22 h;
参考文献
WO2007/65662 A2, ;
Page/Page column 56-57 ;
WO 2007/065662 A2
反应条件
sodium nitrite in sulfuric acid
参考文献
US6608067 B1, ;
US 6608067 B1
反应条件
1: 57 percent / 15percent aq. ammonium sulphide 2: 1.) NaNO2, 2.) H2O View Scheme
参考文献
Phytochemistry, , vol. 41, # 6 p. 1473 - 1475
参考文献
Rolic AG
Patent: US6143208 A1, 2000 ;
参考文献
Drain et al.
Journal of the Chemical Society, 1949 , p. 1498,1502
反应条件
sulfuric acid 18 h; Reflux;
参考文献
WYETH
Patent: US2005/70584 A1, 2005 ;
Location in patent: Page/Page column 24 ;
反应条件
1: 58.2 percent / H2 / PtO2 / ethanol / 3 h
2: pyridine / acetone / 0.33 h / 100 °C
3: aq. NH4OH / methanol / Heating
View Scheme
参考文献
Miyagawa; Ishihara; Kuwahara; Ueno; Mayama
Phytochemistry, 1996 , vol. 41, # 6 p. 1473 - 1475
反应条件
hydrogen; platinum(IV) oxide in ethanol
3 h;
参考文献
Miyagawa; Ishihara; Kuwahara; Ueno; Mayama
Phytochemistry, 1996 , vol. 41, # 6 p. 1473 - 1475
