1: diethyl malonate With sodium ethanolate in ethanol T=80°C; 2: isopropyl bromide in ethanol T=80°C; 11 h; Heating / reflux; 3: urea With hydrogenchloride; ethanol; water; sodium Product distribution / selectivity; more than 3 stages;
参考文献
Gilead Sciences, Inc.; Korea Research Institute of Chemical Technology
Patent: US2009/163712 A1, 2009 ;
Location in patent: Page/Page column 18 ;