2-甲基-3,4,5,6-四甲氧基溴苯合成路线 （共 14 条）
反应条件
bromine in dichloromethane T=3 - 5°C; 0.0833333 h;
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 16 p. 2371 - 2375
反应条件
1: SnCl2; aq. HCl / ethanol 2: 990 mg / aq. KOH / 1 h / 80 °C 3: 84 percent / Br2 / CH2Cl2 / 0.08 h / 3 - 5 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 16 p. 2371 - 2375
反应条件
1: K2CO3 / acetone / 6 h / Heating 2: 2.05 g / N-bromosuccinimide / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 12 p. 2417 - 2420
反应条件
1: 88 percent / Fe; Br2 / CHCl3 / 4 h / 20 °C 2: 66 percent / CuCN; Me2CO3 / 1,2-dimethoxy-ethane; methanol / 120 h / 80 °C 3: K2CO3 / acetone / 6 h / Heating 4: 2.05 g / N-bromosuccinimide / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 12 p. 2417 - 2420
反应条件
1: 66 percent / CuCN; Me2CO3 / 1,2-dimethoxy-ethane; methanol / 120 h / 80 °C 2: K2CO3 / acetone / 6 h / Heating 3: 2.05 g / N-bromosuccinimide / CH2Cl2 / 2 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 12 p. 2417 - 2420
反应条件
1: 990 mg / aq. KOH / 1 h / 80 °C 2: 84 percent / Br2 / CH2Cl2 / 0.08 h / 3 - 5 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 2, # 16 p. 2371 - 2375
反应条件
1: 92 percent / Br2 / CH2Cl2 / -10 °C 2: 1.) n-BuLi / 1.) Et2O, 30 min, 2.) Et2O, 1 h, low temperature, 10 h, room temperature, 3 h, reflux 3: 83 percent / Br2 / CH2Cl2 / 3 - 5 °C View Scheme
参考文献
Tetrahedron, , vol. 36, # 1 p. 123 - 129
反应条件
1: 1.) 75percent H2O2,trifluoroacetic anhydride, 2.) KOH / 1.) CH2Cl2, -40 deg C, 20 min, 2.) MeOH, reflux, 30 min 2: 97 percent / K2CO3 / acetone / 22 h / Heating 3: 92 percent / Br2 / CH2Cl2 / -10 °C 4: 1.) n-BuLi / 1.) Et2O, 30 min, 2.) Et2O, 1 h, low temperature, 10 h, room temperature, 3 h, reflux 5: 83 percent / Br2 / CH2Cl2 / 3 - 5 °C View Scheme
参考文献
Tetrahedron, , vol. 36, # 1 p. 123 - 129
反应条件
1: 97 percent / K2CO3 / acetone / 22 h / Heating 2: 92 percent / Br2 / CH2Cl2 / -10 °C 3: 1.) n-BuLi / 1.) Et2O, 30 min, 2.) Et2O, 1 h, low temperature, 10 h, room temperature, 3 h, reflux 4: 83 percent / Br2 / CH2Cl2 / 3 - 5 °C View Scheme
参考文献
Tetrahedron, , vol. 36, # 1 p. 123 - 129
反应条件
1: 67 percent / conc. HCl, H2, 10percent Pd-C / acetic acid / 120 h 2: 83 percent / Br2 / CH2Cl2 / 3 - 5 °C View Scheme
参考文献
Tetrahedron, , vol. 36, # 1 p. 123 - 129
