6-(O-磷酰胆碱)羟基己酸合成路线 （共 11 条）
反应条件
tetra(n-butyl)ammonium hydroxide T=23°C; Hydrolysis; 12 h;
参考文献
Knopik, Pawel; Bruzik, Karol S.; Stec, Wojciech J.
Organic Preparations and Procedures International, 1991 , vol. 23, # 2 p. 214 - 216
反应条件
Dowex-50(H+) resin in water 0.5 h; steam bath;
参考文献
Spande, Thomas F.
Journal of Organic Chemistry, 1980 , vol. 45, # 15 p. 3081 - 3084
反应条件
18-crown-6 ether in formamide T=110 - 120°C; 3 h; Product distribution / selectivity;
参考文献
US2008/175852 A1, ;
Page/Page column 8 ;
反应条件
1: 89 percent / H2SO4 2: 50 percent / acetonitrile / 15 h / 23 °C 3: 80 percent / aq. tetra-n-butylammonium hydroxide / 12 h / 23 °C View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 23, # 2 p. 214 - 216
反应条件
1: 1) sodium formate, 2) KOH / 1) DMF, a) 110 deg C, 4h, b) RT, 2 days, 2) H2O, 30-40 deg C, 4h 2: 1) triethylamine, 2) pyridine, H2O / 1) RT, 1h, 2) RT 3: 34 percent / CHCl3 / 8 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 15 p. 3081 - 3084
反应条件
1: 1) triethylamine, 2) pyridine, H2O / 1) RT, 1h, 2) RT 2: 34 percent / CHCl3 / 8 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 15 p. 3081 - 3084
反应条件
1: 40 percent / CHCl3 / 8 h / Heating 2: 92 percent / Dowex-50(H+) resin / H2O / 0.5 h / steam bath View Scheme
参考文献
Journal of Organic Chemistry, , vol. 45, # 15 p. 3081 - 3084
反应条件
in chloroform 8 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 45, # 15 p. 3081 - 3084
反应条件
1: 50 percent / acetonitrile / 15 h / 23 °C 2: 80 percent / aq. tetra-n-butylammonium hydroxide / 12 h / 23 °C View Scheme
参考文献
Organic Preparations and Procedures International, , vol. 23, # 2 p. 214 - 216
反应条件
2,6-dimethylpyridine in N,N-dimethyl-formamide Ambient temperature;
参考文献
Spande, Thomas F.
Journal of Organic Chemistry, 1980 , vol. 45, # 15 p. 3081 - 3084
