N-(苯乙酰)-L-苯丙氨酸合成路线 （共 14 条）
反应条件
Escherichia coli penicillin acylase; potassium chloride; water T=24.84°C; pH=6.67; Enzymatic reaction; Equilibrium constant;
参考文献
Guranda, Dorel T.; Ushakov, Gennadij A.; Yolkin, Petr G.; Svedas, Vytas K.
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 74, # 1-2 p. 48 - 53
反应条件
1: Escherichia coli penicillin acylase; potassium chloride; water / 24.84 °C / pH 6.67 / Enzymatic reaction 2: Escherichia coli penicillin acylase; potassium chloride / water / 24.84 °C / pH 5 / Enzymatic reaction View Scheme
参考文献
Guranda, Dorel T.; Ushakov, Gennadij A.; Yolkin, Petr G.; Svedas, Vytas K.
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 74, # 1-2 p. 48 - 53
反应条件
1: With Wang-PEGA resin; acetic anhydride 2: With KPi buffer T=20°C; pH=8.0; 24 h; 3: With trifluoroacetic acid
参考文献
Basso, Alessandra; De Martin, Luigi; Gardossi, Lucia; Margetts, Graham; Brazendale, Ian; Bosma, Annie Y.; Ulijn, Rein V.; Flitsch, Sabine L.
Chemical Communications, 2003 , # 11 p. 1296 - 1297
反应条件
Escherichia coli penicillin acylase; potassium chloride; water T=24.84°C; pH=6.67; Enzymatic reaction; Equilibrium constant;
参考文献
Guranda, Dorel T.; Ushakov, Gennadij A.; Yolkin, Petr G.; Svedas, Vytas K.
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 74, # 1-2 p. 48 - 53
反应条件
1: With recombinant Alcaligenes faecalis penicillin G acylase immobilized on oxirane acrylic carrier; potassium hydroxide in water
T=35°C; pH=10; 3.66667 h; Enzymatic reaction;
2: With hydrogenchloride in water
pH=1; optical yield given as percent eeenantioselective reaction;
参考文献
Gong, Xiangyu; Su, Erzheng; Wang, Pixiang; Wei, Dongzhi
Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5398 - 5402
反应条件
1: With recombinant Alcaligenes faecalis penicillin G acylase immobilized on oxirane acrylic carrier; potassium hydroxide in water
T=35°C; pH=10; 2.33333 h; Enzymatic reaction;
2: With hydrogenchloride in water
pH=1; optical yield given as percent eeenantioselective reaction;
参考文献
Gong, Xiangyu; Su, Erzheng; Wang, Pixiang; Wei, Dongzhi
Tetrahedron Letters, 2011 , vol. 52, # 41 p. 5398 - 5402
反应条件
hydrogen bromide in nitromethane; water
T=70°C;
参考文献
Obrecht; Spiegler; Schonholzer; Muller; Heimgartner; Stierli
Helvetica Chimica Acta, 1992 , vol. 75, # 5 p. 1666 - 1696
反应条件
potassium phosphate in tetrahydrofuran
T=20°C; 12 h; Inert atmosphere;
参考文献
Zhang, Li; Wang, Xiao-jun; Wang, Jing; Grinberg, Nelu; Krishnamurthy, DhileepKumar; Senanayake, Chris H.
Tetrahedron Letters, 2009 , vol. 50, # 24 p. 2964 - 2966
反应条件
1: CH2Cl2 / 12 h / Ambient temperature
2: 78 percent / HBr / nitromethane; H2O / 70 °C
View Scheme
参考文献
Obrecht; Spiegler; Schonholzer; Muller; Heimgartner; Stierli
Helvetica Chimica Acta, 1992 , vol. 75, # 5 p. 1666 - 1696
反应条件
1: DCC / CH2Cl2 / 0.5 h / Ambient temperature
2: CH2Cl2 / 12 h / Ambient temperature
3: 78 percent / HBr / nitromethane; H2O / 70 °C
View Scheme
参考文献
Obrecht; Spiegler; Schonholzer; Muller; Heimgartner; Stierli
Helvetica Chimica Acta, 1992 , vol. 75, # 5 p. 1666 - 1696
