4-氨基-2-氟苯甲酸乙酯合成路线 （共 6 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
Teng; Duong; Klein; Pino; Chandraratna
Journal of Medicinal Chemistry, 1996 , vol. 39, # 16 p. 3035 - 3038
反应条件
1: SOCl2 / 80 °C 2: pyridine / CH2Cl2 3: 100 percent / H2 / Pd/C / ethyl acetate View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 16 p. 3035 - 3038
反应条件
1: Na2Cr2O7, H2SO4 / acetic acid / 90 °C 2: SOCl2 / 80 °C 3: pyridine / CH2Cl2 4: 100 percent / H2 / Pd/C / ethyl acetate View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 16 p. 3035 - 3038
反应条件
1: pyridine / CH2Cl2 2: 100 percent / H2 / Pd/C / ethyl acetate View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 39, # 16 p. 3035 - 3038
反应条件
1: 3-nitro-6-methyl-fluorobenzene With sodium dichromate; sulfuric acid in acetic acid T=90°C; 2: With thionyl chloride 3: ethanol With hydrogen; palladium over charcoal more than 3 stages;
参考文献
US6342602 B1, ;
Page column 20,28 ;
反应条件
in acetic acid
T=80°C;
参考文献
ARAGON PHARMACEUTICALS, INC.; SMITH, Nicholas, D.; BONNEFOUS, Celine; JULIEN, Jackaline, D.
Patent: WO2011/103202 A2, 2011 ;
Location in patent: Page/Page column 167 ;
WO 2011/103202 A2
