4-碘-2-甲基-1H-咪唑合成路线 （共 10 条）
反应条件
sodium sulfite in ethanol; water T=100°C; 24 h;
参考文献
Hendricks, Robert Than; Hermann, Johannes; Kondru, Rama; Lou, Yan; Lynch, Stephen M.; Owens, Timothy D.; Soth, Michael
Patent: US2011/230462 A1, 2011 ;
Location in patent: Page/Page column 109 ;
US 20110230462 A1
反应条件
in tetrahydrofuran; water
反应条件
sodium nitrate; perchloric acid; triiodide monoanion; iodide in water T=30°C; 48 h; buffer and hydrogen ion dependence; KineticsMechanism;
参考文献
Journal of Organic Chemistry, , vol. 45, # 15 p. 3108 - 3111
反应条件
sodium carbonate in N,N-dimethyl-formamide T=120°C; 16 h;
参考文献
Bell, Andrew S.; Campbell, Simon F.; Morris, David S.; Roberts, David A.; Stefaniak, Mark H.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1552 - 1558
参考文献
Pfizer Inc.
Patent: US4728653 A1, 1988 ;
反应条件
triethylamine in N,N-dimethyl-formamide
参考文献
Zeng, Jing; Bai, Yaguang; Cai, Shuting; Ma, Jimei; Liu, Xue-Wei
Chemical Communications, 2011 , vol. 47, # 48 p. 12855 - 12857
反应条件
tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide in tetrahydrofuran; DMF (N,N-dimethyl-formamide)
T=20 - 60°C;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2005/3117 A1, 2005 ;
Location in patent: Page/Page column 22-23 ;
反应条件
copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=60°C; 1.5 h; Inert atmosphere;
参考文献
F. HOFFMANN-LA ROCHE AG; JAESCHKE, Georg; LINDEMANN, Lothar; VIEIRA, Eric; WICHMANN, Juergen
Patent: WO2011/6910 A1, 2011 ;
Location in patent: Page/Page column 13 ;
WO 2011/006910 A1
反应条件
tetrabutyl ammonium fluoride; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine in tetrahydrofuran; N,N-dimethyl-formamide
T=20°C;
参考文献
Buettelmann, Bernd; Ceccarelli, Simona Maria; Jaeschke, Georg; Kolczewski, Sabine; Porter, Richard Hugh Philip; Vieira, Eric
Patent: US2004/254179 A1, 2004 ;
Location in patent: Page/Page column 13 ;
US 20040254179 A1
反应条件
caesium carbonate in N,N-dimethyl-formamide
18 h; Heating;
参考文献
Hendricks, Robert Than; Hermann, Johannes; Kondru, Rama; Lou, Yan; Lynch, Stephen M.; Owens, Timothy D.; Soth, Michael
Patent: US2011/230462 A1, 2011 ;
Location in patent: Page/Page column 110 ;
US 20110230462 A1
