4-异硫氰酸基哌啶-1-羧酸乙酯合成路线 （共 8 条）
反应条件
1: ethanol 2: sulfur; mercury(II) oxide / ethanol / Heating 3: sodium carbonate / N,N-dimethyl-formamide / 70 °C View Scheme
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
triethylamine in dichloromethane
T=0 - 20°C; 1 h;
参考文献
PFIZER INC.
Patent: WO2004/74283 A1, 2004 ;
Location in patent: Page 33; 34; 219 ;
WO 2004/074283 A1
反应条件
carbon disulfide; sodium hydroxide in water
参考文献
Janssen Pharmaceutica N.V.
Patent: US4943580 A1, 1990 ;
反应条件
sodium hydroxide; chloroformic acid ethyl ester
1.) water, 10 deg C, 30 min, 2.) water, 60 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Janssens; Torremans; Janssen; Stokbroekx; Luyckx
Journal of Medicinal Chemistry, 1985 , vol. 28, # 12 p. 1925 - 1933
反应条件
1: 100 percent / ethanol / Ambient temperature
2: 55.5 percent / yellow HgO, sulfur / ethanol / 2 h / Heating
View Scheme
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
1: ethanol / 20 °C
2: mercury(II) oxide / ethanol / 2 h / |Reflux
3: hydrogen bromide / 2 h / |Reflux
View Scheme
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
1: ethanol / 20 °C
2: mercury(II) oxide / ethanol / 2 h / |Reflux
3: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 20 h / 70 - 80 °C
4: hydrogen bromide / 2 h / |Reflux
View Scheme
参考文献
Roman, Gheorghe; Crandall, Ian E.; Szarek, Walter A.
ChemMedChem, 2013 , vol. 8, # 11 p. 1795 - 1804
反应条件
1: ethanol
2: sulfur; mercury(II) oxide / ethanol / Heating
3: sodium carbonate / N,N-dimethyl-formamide / 70 °C
4: hydrogen bromide / 3 h / Reflux
View Scheme
参考文献
Wagner, Eva; Wittmann, Hans-Joachim; Elz, Sigurd; Strasser, Andrea
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6274 - 6280
