N-[(9H-芴-9-甲氧基)羰基]-L-苏氨酸苯基甲酯合成路线 （共 8 条）
反应条件
1: 1.) AgClO4, 4A molecular sieves / 1.) CH2Cl2, RT, 10 min, 2.) CH2Cl2, RT, overnight 2: 76 percent / pyridine / 20 h / Ambient temperature 3: 92 percent / H2 / 5percent Pd/C / methanol; H2O / 90 h / 760 Torr View Scheme
参考文献
Andreotti, Amy Hamilton; Kahne, Daniel
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3352 - 3353
反应条件
piperidine in N,N-dimethyl-formamide T=20°C; 0.333333 h;
参考文献
Campo, Vanessa L.; Sesti-Costa, Renata; Carneiro, Zumira A.; Silva, Joao S.; Schenkman, Sergio; Carvalho, Ivone
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 1 p. 145 - 156
反应条件
1: N-Fmoc-L-threonine-OH With caesium carbonate in methanol
0.25 h; Inert atmosphere;
2: benzyl bromide in N,N-dimethyl-formamide
T=20°C; Inert atmosphere;
参考文献
Loke, Inga; Park, Natja; Kempf, Karl; Jagusch, Carsten; Schobert, Rainer; Laschat, Sabine
Tetrahedron, 2012 , vol. 68, # 2 p. 697 - 704
反应条件
N,N-diethyl-N-isopropylamine in dichloromethane
T=0°C; 1 h;
参考文献
Mitchell; Pratt; Hruby; Polt
Journal of Organic Chemistry, 2001 , vol. 66, # 7 p. 2327 - 2342
反应条件
sodium hydrogencarbonate in 1,4-dioxane
24 h;
参考文献
Lacombe, J. M.; Pavia, A. A.
Journal of Organic Chemistry, 1983 , vol. 48, # 15 p. 2557 - 2563
反应条件
triethylamine in dichloromethane
参考文献
Varon, Daniel; Lioy, Eduardo; Patarroyo, Manuel E.; Schratt, Xaver; Unverzagt, Carlo
Australian Journal of Chemistry, 2002 , vol. 55, # 1-2 p. 161 - 165
反应条件
1.1: sodium carbonate / 1,4-dioxane; water / 20 °C / Inert atmosphere
1.2: pH 4
2.1: caesium carbonate / methanol / 0.25 h / Inert atmosphere
2.2: 20 °C / Inert atmosphere
View Scheme
参考文献
Loke, Inga; Park, Natja; Kempf, Karl; Jagusch, Carsten; Schobert, Rainer; Laschat, Sabine
Tetrahedron, 2012 , vol. 68, # 2 p. 697 - 704
反应条件
1: 78 percent / DMTST, MS 4 Angstroem / CH2Cl2 / 1.5 h / Ambient temperature
2: 1.) Zn, AcOH, 2.) Pyr / 1.) room temperature, 20 h, 2.) room temperature, 3 h.
3: 88 percent / 5percent Pd/C / ethyl acetate; ethanol / 1.5 h / Ambient temperature
View Scheme
参考文献
Talat, Sariya; Thiruvikraman, Menithalakshmi; Kumari, Saroj; Kaur, Kanwal J.
Glycoconjugate Journal, 2011 , vol. 28, # 8-9 p. 537 - 555
